Jason J. Paris

Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1

Pankaj Pandey, A H Zagzoog, Theodor Zaharia, Shamba Chatterjee et autres

While Δ9-tetrahydrocannabinol (THC) offers significant pain relief, its psychoactive side effects limit its clinical utility. The discovery of cannabidiol (CBD) as a negative allosteric modulator (NAM) of cannabinoid receptor 1 (CB1R) establishes allosteric targeting as a viable framework for refining cannabinoid-based therapeutics. …

us, ca (code pays fourni par la source)

Early Life Exposure to Δ 9 -Tetrahydrocannabinol Causes Persistent Growth, Behavior, and Bioenergetic Outcomes in Zebrafish

Zacharias Pandelides, Cammi Thornton, Jason J. Paris, Nicole M. Ashpole et autres

Introduction: Although classified in the United States as Schedule I drugs, medical and recreational cannabis and Δ 9 -tetrahydrocannabinol (THC) are becoming increasingly consumed by pregnant women. Determining the potential adverse effects following exposure during early development is essential for risk communication. …

us (code pays fourni par la source)

Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice

Alaa N. Qrareya, Emaya M. Moss, Fakhri Mahdi, Mohammed Salahuddin et autres

Objecives: Approximately 80 % of people living with HIV (PLWH) develop chronic pain and preclinical studies support the involvement of the HIV-1 regulatory protein, trans-activator of transcription (Tat). Phytocannabinoids may attenuate pain in PLWH; however, these data are controversial, and the biological …

us (code pays fourni par la source)

Physiological and Psychological Impacts of Shift Work Among Student Pharmacists: Sex Differences in Stress and Health Outcomes

Salahuddin Mohammed, Richard Bugingo, Fakhri Mahdi, Delilah Spencer et autres

Shift work is prevalent among healthcare professionals and associated with significant health risks, including stress, sleep disturbances, and mood disorders. Despite known sex differences in stress responses, their impact on shift workers, particularly student pharmacists, is understudied. The objective of this study …

us, sa (code pays fourni par la source)

HIV-1 Tat Impairment of Mitochondrial Respiration via Complexes I and II Can Be Ameliorated by Allopregnanolone in Opioid-Exposed or Opioid-Naïve Cells and Mice

Fakhri Mahdi, Zia Shariat‐Madar, Jason J. Paris

HIV-associated neurocognitive disorders are prevalent despite antiretroviral intervention. Some HIV virotoxins, such as the trans-activator of transcription (Tat), are not targeted by antiretrovirals, and their neurotoxic actions may be exacerbated by opioids. Both Tat and morphine disrupt mitochondrial function, which may promote …

us (code pays fourni par la source)

Sex related differences in cognitive deficits: Disrupted Arc/Arg3.1 signaling in an HIV model

Yun-Kyung Hahn, Sara R. Nass, William Dennis Marks, Jason J. Paris et autres

us (code pays fourni par la source)

Enhancing Neurosteroidogenesis Attenuates HIV-1 Tat Mediated Stress-Related Outcomes

Salahuddin Mohammed, Fakhri Mahdi, Jason J. Paris

Objective: To investigate the potential role of the neurotoxic HIV-1 regulatory protein, trans-activator of transcription (Tat), in hypothalamic-pituitary-adrenal (HPA) axis dysfunction and associated affective disorders, and to explore the hypothesis that enhancing neurosteroidogenesis could ameliorate Tat-mediated HPA dysfunction.

us (code pays fourni par la source)

Increased Prolylcarboxypeptidase Expression Can Serve as a Biomarker of Senescence in Culture

Nicholas Glen Boullard, Jason J. Paris, Zia Shariat‐Madar, Fakhri Mahdi

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin- and kinin-induced cell signaling. Elevation of PRCP appears to be activated in chronic inflammatory diseases [cardiovascular disease (CVD), diabetes] in proportion to severity. Vascular endothelial cell senescence and mitochondrial dysfunction have consistently been …

us (code pays fourni par la source)

Ionic Liquid Coating‐Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV

Christine M. Hamadani, Fakhri Mahdi, Anya Merrell, Jack Flanders et autres

Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate HIV, and given CNS infection, …

us (code pays fourni par la source)

Increased Prolylcarboxypeptidase Expression Can Serve as Biomarker of Senescence in Culture

Nicholas Glen Boullard, Jason J. Paris, Zia Shariat‐Madar, Fakhri Mahdi

Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin - and kinin- induced cell signaling. Elevation of PRCP appear to be activated in chronic inflammatory diseases (cardiovascular disease (CVD), diabetes) in proportion to severity. Vascular endothelial cell senescence and mitochondrial dysfunction have …

us (code pays fourni par la source)

Contributors

Ravikumar Aalinkeel, Cristian L. Achim, Jonathan Ahern, Mohammad Sobhan Sheikh Andalibi et autres

us (code pays fourni par la source)

The role of HIV-associated neuroendocrine dysfunction in HAND

Jason J. Paris

us (code pays fourni par la source)