Donghai Yu

EMB is essential for enteric nervous system development mediated by PI3K signaling

Zhi Li, Didi Zhuansun, Xinyao Meng, Heying Yang et autres

BACKGROUND: The enteric nervous system (ENS), which arises from enteric neural crest cells (ENCCs), plays important roles in many aspects of gastrointestinal tract function, including motility, secretions, blood flow and hormone release. Defects in ENS development could lead to a broad range …

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Rare and common genetic variants underlying the risk of Hirschsprung’s disease

Jun Xiao, Chenzhao Feng, Tianqi Zhu, Xuan Zhang et autres

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans …

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Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos

Bingyan Zhou, Chenzhao Feng, Song Sun, Xuyong Chen et autres

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Transanal full-thickness pull-through approach in the treatment of anastomotic leakage after operation for Hirschsprung disease

Chunlei Jiao, Didi Zhuansun, Ying He, Pei Wang et autres

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Inflammatory Myofibroblastic Tumor of the Sigmoid Colon in an Infant: A Case Report and Literature Review

Luyao Wu, Xinyao Meng, Jing Wang, Qiong Wang et autres

Inflammatory myofibroblastic tumor (IMT) infrequently involves the sigmoid colon, and has not previously been described in an infant sigmoid colon. An inflammatory myofibroblastic tumor arose from the sigmoid colon of an 11-month-old boy, confirmed by anaplastic lymphoma kinase (ALK), smooth muscle actin …

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Carbenoxolone does not Improve Sevoflurane-induced Neurotoxicity in the Developing Rat Hippocampus

Congjie Bi, Dan Xie, Donghai Yu, Yang Wang

Abstract Background: Connexin 43 is the most abundant connexin protein expressed in astrocytes. Our previous research found that sevoflurane-induced neurotoxicity was related to Cx43 via JNK/MAPK/Ap-1 signaling pathway. Cx43 functions through hemichannels (HCs) and gap junctions (GJs) and both of them could …

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PRDM14 mediates chemosensitivity and glycolysis in drug‑resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells

Saifei He, Xiaokun Ma, Ni Zheng, Guoyu Wang et autres

Recent studies have reported that aberrant PR domain zinc finger protein 14 (PRDM14) expression is associated with the therapeutic sensitivity of cancer cells to drugs. However, its role in lung adenocarcinoma (LUAD) remains unclear. The present study aimed to determine the functions …

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Efficacy and Safety of Acupuncture at Tianshu (ST25) for Functional Constipation: Evidence from 10 Randomized Controlled Trials

Pengfan Li, Yue Luo, Qi Wang, Shi Shu et autres

OBJECTIVE: To evaluate the evidence for the efficacy and safety of acupuncture at Tianshu (ST25) for functional constipation (FC). METHODS: We systematically searched seven databases to identify randomized controlled trials of acupuncture at ST25 alone or in combination with conventional therapy in …

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Management experiences of colorectal duplication in children: a report of 7 cases

Donghai Yu, Jia Shi, Yimin Gong, Wenjie Wu

Objective To explore the diagnosis and treatment of colorectal duplications, and to improve its treatment outcomes. Methods Four boys and 3 girls with colorectal duplications between January 2001 and June 2017 were reviewed. Their clinical features, diagnosis, concomitant anomalies and treatment were …

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Endoscopic biliary drainage management for children with serious cholangitis caused by congenital biliary dilatation

Bin Sun, Donghai Yu, Chen Ji, Yonghui Tang et autres

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A Long-Term Follow-Up of a New Surgery Method: Laparoscope-Assisted Heart-Shaped Anastomosis for Hirschsprung's Disease

Chunlei Jiao, Donghai Yu, Dandan Li, Wang Guo et autres

BACKGROUND: Laparoscopic surgery is widely used in the treatment of Hirschsprung's disease (HD). However, constipation and soiling are still the main long-term complications. A new type of anastomosis, which is characterized by a heart-shaped colorectal anastomosis after splitting the posterior rectum wall …

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The prevalence and progression of mild cognitive impairment among clinic and community populations: a systematic review and meta-analysis

Chengping Hu, Donghai Yu, Xirong Sun, Ming Qiu Zhang et autres

BACKGROUND: It has been reported that up to 42% of the population aged over 60 are affected by mild cognitive impairment (MCI) worldwide. This study aims to investigate the prevalence and progression of MCI through a meta-analysis. METHODS: We searched Embase and …

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