Xinyao Meng

The EMB/ATG7-mediated autophagic process regulates neurite outgrowth and promotes enteric neuronal development

Luyao Wu, Yi-Xiang Wang, Jing Wang, Jun Xiao et autres

The formation of the enteric nervous system (ENS) primarily involves the migration of enteric neural crest-derived cells (ENCCs) and the subsequent maturation of enteric neurons. The developmental dysfunction of ENCCs and enteric neurons can result in ENS disorders, such as hypoganglionosis (HG). …

us, cn (code pays fourni par la source)

The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations

Tianqi Zhu, Xinyao Meng, Qun Hu, Ke Chen et autres

cn (code pays fourni par la source)

Distal-less homeobox 5 transactivated by MYCN contributes to progression of neuroblastoma through AKT signaling pathway

Yi He, Xiaosi Yu, Chenzhao Feng, Ke Gong Chen et autres

Neuroblastoma is one of the highest incidence solid tumors of childhood. Therapy for neuroblastoma with MYCN proto-oncogene (MYCN) amplification is of great challenge, due to its aggressive invasion and chemoresistance. In our study, differentially expressed genes (DEGs) between MYCN-amplified and non-amplified neuroblastoma …

cn (code pays fourni par la source)

EMB is essential for enteric nervous system development mediated by PI3K signaling

Zhi Li, Didi Zhuansun, Xinyao Meng, Heying Yang et autres

BACKGROUND: The enteric nervous system (ENS), which arises from enteric neural crest cells (ENCCs), plays important roles in many aspects of gastrointestinal tract function, including motility, secretions, blood flow and hormone release. Defects in ENS development could lead to a broad range …

cn, qa (code pays fourni par la source)

The essential role of cytoskeleton and ciliary system alterations in the development of congenital pulmonary airway malformations

Tianqi Zhu, Xinyao Meng, Qun Hu, Ke Chen et autres

cn (code pays fourni par la source)

Integrated bulk and single-cell RNA sequencing reveals a cuproptosis-related LncRNA prognostic signature in neuroblastoma

Ke Chen, Jing Wang, Jun Xiao, Luyao Wu et autres

BACKGROUND: Neuroblastoma (NB), the most common extracranial solid tumor of childhood, originates from developing sympathetic nervous system. While cuproptosis has emerged as a critical regulator in oncobiology, its mechanistic involvement in NB remains poorly characterized. METHODS: RNA-seq data of NB patients was …

us, cn, th (code pays fourni par la source)

Three distinct classes of myenteric ganglia in mice and humans: insights from quantitative analyses

Luyao Wu, Lei Xiang, Yingjian Chen, Handan Mao et autres

Background: The myenteric plexus primarily consists of the myenteric ganglia, which include enteric neurons, synaptic neuropils, and glial cells. Abnormal myenteric plexus formation can result in gastrointestinal disorders. Comprehensive morphological classification studies of myenteric ganglia remain limited. Methods: Whole-mount immunofluorescence staining was …

cn (code pays fourni par la source)

A biodegradable capacitive-coupling neurostimulator for wireless electroceutical treatment of inflammatory bowel diseases

Qiong Wang, Ming Yang, Renyuan Sun, W.X. Liu et autres

Electroceuticals based on peripheral nerve stimulation offer promising treatment for refractory inflammatory diseases such as inflammatory bowel diseases (IBDs). For pediatric IBD (PIBD) patients, wireless, biodegradable miniaturized bioelectronic devices are crucial to prevent neural damage and support neural development during and after …

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Rare and common genetic variants underlying the risk of Hirschsprung’s disease

Jun Xiao, Chenzhao Feng, Tianqi Zhu, Xuan Zhang et autres

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans …

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Corrigendum to “Mesenchymal Stem Cells Attenuates Hirschsprung diseases-Associated Enterocolitis by Reducing M1 Macrophages Infiltration via COX-2 Dependent Mechanism” [J Pediatr Surg 59 (2024) 1498–1514]

Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun et autres

cn (code pays fourni par la source)

Exploring causal association between malnutrition, nutrients intake and inflammatory bowel disease: a Mendelian randomization analysis

Shi Wang, Jing Wang, Xinyao Meng, Shimin Yang et autres

Background: Malnutrition has emerged as main side effects of inflammatory bowel disease (IBD) which might also affect the prognosis of IBD. However, whether these associations are causal remains unclear. We aimed to identify the causality of IBD on malnutrition and explore the …

hk, cn (code pays fourni par la source)

Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos

Bingyan Zhou, Chenzhao Feng, Song Sun, Xuyong Chen et autres

cn (code pays fourni par la source)