Chunlei Jiao

The EMB/ATG7-mediated autophagic process regulates neurite outgrowth and promotes enteric neuronal development

Luyao Wu, Yi-Xiang Wang, Jing Wang, Jun Xiao et autres

The formation of the enteric nervous system (ENS) primarily involves the migration of enteric neural crest-derived cells (ENCCs) and the subsequent maturation of enteric neurons. The developmental dysfunction of ENCCs and enteric neurons can result in ENS disorders, such as hypoganglionosis (HG). …

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EMB is essential for enteric nervous system development mediated by PI3K signaling

Zhi Li, Didi Zhuansun, Xinyao Meng, Heying Yang et autres

BACKGROUND: The enteric nervous system (ENS), which arises from enteric neural crest cells (ENCCs), plays important roles in many aspects of gastrointestinal tract function, including motility, secretions, blood flow and hormone release. Defects in ENS development could lead to a broad range …

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Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos

Bingyan Zhou, Chenzhao Feng, Song Sun, Xuyong Chen et autres

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Rhabdomyosarcoma of the gallbladder in a child: A case report

Adila Abudusalamu, Wenjing Wang, Jing Wang, Chunlei Jiao et autres

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The most common sites are the head and neck, followed by the genitourinary tract and the extremities. Gallbladder RMS in pediatric patient has rarely been reported in literature. A 5-year-old boy …

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The utility of the 24-h delayed film of barium enema for detecting the dysganglionic bowel segment in Hirschsprung’s disease

Bingyan Zhou, Di Wang, Ke Chen, Yonghua Niu et autres

Background: Preoperative evaluation of the dysganglionic bowel segment is critical for establishing the optimal resection strategy for Hirschsprung's disease (HSCR), which facilitates patient outcomes. Objective: We set out to determine the utility of the 24-h delayed film of barium retention in predicting …

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Transanal full-thickness pull-through approach in the treatment of anastomotic leakage after operation for Hirschsprung disease

Chunlei Jiao, Didi Zhuansun, Ying He, Pei Wang et autres

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Diaphyseal and Metaphyseal Modeling Defects—Clinical Findings and Identification of WRAP53 Deficiency in Craniometadiaphyseal Dysplasia

Yun Xiu Hao, Xiaolin Wang, Jun Xiao, Chunlei Jiao et autres

Background: Diaphyseal and metaphyseal modeling defects lead to severe changes in bone mass and shape, which are common features in osteoporosis that linked to non-vertebral fractures. Original mechanism of diaphyseal and metaphyseal modeling defects has proved elusive. Studying rare syndromes can elucidate …

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Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis

Xue Xia, Di Wang, Lei Yu, Bin Wang et autres

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Intestinal proinflammatory macrophages induce a phenotypic switch in interstitial cells of Cajal

Xuyong Chen, Xinyao Meng, Hongyi Zhang, Chenzhao Feng et autres

Interstitial cells of Cajal (ICCs) are pacemaker cells in the intestine, and their function can be compromised by loss of C-KIT expression. Macrophage activation has been identified in intestine affected by Hirschsprung disease-associated enterocolitis (HAEC). In this study, we examined proinflammatory macrophage …

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Intravenous antibiotics for the treatments of cholangitis after Kasai operation in biliary atresia patients

Pei Wang, Dandan Li, Chunlei Jiao, Didi Zhuansun et autres

Abstract Objective: This is a single-center, retrospective study, to assess the experimental treatment of intravenous antibiotics for cholangitis after Kasai portoenterostomy (PKE) in biliary atresia (BA) patients.Methods: 153 cholangitis patients after PKE from January 2016 to December 2018 were retrospectively reviewed. Based …

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Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis

C C Lee, RD Southgate, Chunlei Jiao, E Gersz et autres

Staphylococcus aureus (S. aureus) osteomyelitis remains a major clinical problem. Anti-glucosaminidase (Gmd) antibodies (1C11) are efficacious in prophylactic and therapeutic murine models. Feasibility, safety and pharmacokinetics of 1C11 passive immunisation in sheep and endogenous anti-Gmd levels were quantified in osteomyelitis patients. 3 …

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A Study of Three-Dimensional Versus Two-Dimensional Laparoscopic Surgery in Resection of Congenital Choledochal Cyst of Children and Jejunum Roux-en-Y Anastomosis

Didi Zhuansun, Chunlei Jiao, Xinyao Meng, Jun Xiao et autres

Background: This study aimed to explore the clinical efficacy of three-dimensional (3D) laparoscopic surgery in the treatment of congenital choledochal cysts (CCCs) by comparing it with two-dimensional (2D) laparoscopic surgery. Patients and Methods: We retrospectively reviewed data of 155 pediatric patients who …

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