Chenzhao Feng

Invas: an inversion-aware method for transcriptome assembly

Xuedong Wang, Fang Wang, Chenzhao Feng, Chaoyang Sun et autres

Intragenic inversions reverse sequence orientation within genes and create non-collinear splice junctions that standard transcript assemblers miss, resulting in incomplete reconstruction and biased quantification. Here we show Invas, an inversion-aware framework operating with bulk short-read sequencing data. Invas integrates whole-genome sequencing breakpoints …

hk, cn (code pays fourni par la source)

Cancer-derived IGKC Suppresses Interferon Signaling and Promotes Tumor Metastasis

C Sun, Xucui Zhuang, Zixuan Fang, Liu Y et autres

cn, sa (code pays fourni par la source)

Spatial tumor evolution panorama of ovarian cancer

Chenzhao Feng, Yunyi Yang, Guanchu Li, Zixuan Fang et autres

Ovarian cancer is an aggressive disease characterized by intraperitoneal dissemination and a distinctive microenvironment. By generating metastatic cohorts encompassing approximately 60 pairs of whole-genome and RNA sequencing, 100 single-cell samples, and 2.5 million spatial transcriptomics (ST) spots, we delineate site-specific tumor-host colocalization …

cn, us (code pays fourni par la source)

Hypoxia-driven remodeling of SELENOP+ macrophages shapes T cell dynamics and promotes ovarian cancer metastasis

Qing Liu, Chenzhao Feng, Tianhao Wu, Siyang Zhang et autres

Abstract High-grade serous ovarian cancer (HGSOC) is characterized by extensive transcoelomic dissemination and the accumulation of ascites. However, how site-specific tumor microenvironment (TME) drives progression remains unknown. Here we show the co-occurrence and spatial co-localization of SELENOP + macrophages and precursor exhausted …

cn, kn (code pays fourni par la source)

Mapping the immune cells of the testis: Key insights into sexaual maturation

Xiaoyu Wu, Chenzhao Feng, Zunpan Fan, Yongfeng Wang et autres

cn (code pays fourni par la source)

Distal-less homeobox 5 transactivated by MYCN contributes to progression of neuroblastoma through AKT signaling pathway

Yi He, Xiaosi Yu, Chenzhao Feng, Ke Chen et autres

Neuroblastoma is one of the highest incidence solid tumors of childhood. Therapy for neuroblastoma with MYCN proto-oncogene (MYCN) amplification is of great challenge, due to its aggressive invasion and chemoresistance. In our study, differentially expressed genes (DEGs) between MYCN-amplified and non-amplified neuroblastoma …

cn (code pays fourni par la source)

EMB is essential for enteric nervous system development mediated by PI3K signaling

Zhi Li, Didi Zhuansun, Xinyao Meng, Heying Yang et autres

BACKGROUND: The enteric nervous system (ENS), which arises from enteric neural crest cells (ENCCs), plays important roles in many aspects of gastrointestinal tract function, including motility, secretions, blood flow and hormone release. Defects in ENS development could lead to a broad range …

cn, qa (code pays fourni par la source)

Mapping the immune cells of the testis: Key insights into sexual maturation

Xiaoyu Wu, Chenzhao Feng, Zunpan Fan, Yongfeng Wang et autres

Abstract Background The testicular immune microenvironment sustains homeostasis and immune privilege. However, the presence and functional significance of B cells within this specialized niche remain poorly characterized. Furthermore, the intricate crosstalk between resident immune populations and testicular stromal cells that may orchestrate …

cn (code pays fourni par la source)

Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models

Xingyuan Hu, X. S. Kang, Faming Zhao, Yaoyuan Cui et autres

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade …

cn (code pays fourni par la source)

Risk of ovarian cancer in women with pelvic inflammatory disease and homologous recombination repair gene mutations under 55: a population-based cohort study

Chenzhao Feng, Wanwan Luo, Zanhong Wang, Xi Cao et autres

OBJECTIVE: To address the relation among pelvic inflammatory disease (PID), genetic vulnerability and ovarian cancer (OC) risk, we assessed the association between PID and OC risk, alongside the interplay with germline homologous recombination repair (gHR) mutation, utilizing the UK Biobank. METHODS: ) …

cn (code pays fourni par la source)

Rare and common genetic variants underlying the risk of Hirschsprung’s disease

Jun Xiao, Chenzhao Feng, Tianqi Zhu, Xuan Zhang et autres

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans …

cn (code pays fourni par la source)

Corrigendum to “Mesenchymal Stem Cells Attenuates Hirschsprung diseases-Associated Enterocolitis by Reducing M1 Macrophages Infiltration via COX-2 Dependent Mechanism” [J Pediatr Surg 59 (2024) 1498–1514]

Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun et autres

cn (code pays fourni par la source)