Xuan Zhang

FXYD1 dysregulation impairs trophoblast function via a miR-486-3p-regulated axis in recurrent miscarriage

Jie Gan, Shuhan Yang, Yan Shi, Yu Zhang et autres

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POS0834 AGE-RELATED DIFFERENCES IN CLINICAL AND IMMUNOLOGICAL FEATURES OF PRIMARY SJÖGREN'S SYNDROME: A CROSS-SECTIONAL STUDY

Qian Li, Q. Y. Su, Yulan Duan, Shunying Zhao et autres

Background: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by dry mouth and dry eyes, often leading to significant impairment in quality of life [1]. The clinical presentation, disease activity, and immune response can vary between patients with early onset …

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Analysis of the causes of redo pull-through for recurrent constipation and the risk factors affecting the prognosis of the Hirschsprung’s disease: a single-center retrospective study and systematic review

Jun Xiao, Shimin Yang, Lei Xiang, Bo Qin et autres

BACKGROUND: Hirschsprung's disease (HSCR) is a congenital gastrointestinal disorder. Pull-through (PT) surgery, the primary treatment, often leads to recurrent constipation. The causes of redo pull-through (redo-PT) for recurrent constipation remain unclear, with limited research on follow-up outcomes and prognostic factors. METHODS: We …

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The BMP Signaling Pathway: Bridging Maternal-Fetal Crosstalk in Early Pregnancy

Shuhan Yang, Jie Gan, Haoran Xu, Jiaxin Shi et autres

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FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity

Jie Gan, Long Yang, Shuhan Yang, Wenwen Gu et autres

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Rare and common genetic variants underlying the risk of Hirschsprung’s disease

Jun Xiao, Chenzhao Feng, Tianqi Zhu, Xuan Zhang et autres

Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans …

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MNSFβ promotes LPS-induced TNFα expression by increasing the localization of RC3H1 to stress granules, and the interfering peptide HEPN2 reduces TNFα production by disrupting the MNSFβ–RC3H1 interaction in macrophages

Hanyu Jiang, Wenwen Gu, Jie Gan, Qian Yang et autres

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Cinchophen induces RPA1 related DNA damage and apoptosis to impair ENS development of zebrafish

Jing Wang, Xinyao Meng, Xuyong Chen, Jun Xiao et autres

Nonsteroidal anti-inflammatory drugs (NSAIDs) have become contaminants widely distributed in the environment due to improper disposal and discharge. Previous study has found several components might involve in impairing enteric nervous system (ENS) development of zebrafish, including NSAIDs cinchophen. Deficient ENS development in …

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MiR-3074-5p Regulates Trophoblasts Function via EIF2S1/GDF15 Pathway in Recurrent Miscarriage

Jiaxin Shi, Yang Long, Jie Gan, Wenwen Gu et autres

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Association of human leukocyte antigen‐G and ‐F with recurrent miscarriage and implantation failure: A systematic review and meta‐analysis

Nana Han, Wanting Xia, Can Zhu, Xuan Zhang et autres

PROBLEM: The immune system plays an essential role in embryonic implantation and pregnancy, but the molecular details remain controversial. In the past four decades, human leukocyte antigen (HLA)-G and -F have garnered significant attention. METHOD OF STUDY: MEDLINE, EMBASE, Web of Science, …

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Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss

Yan Gu, Ning Song, Wenwen Gu, Linghan Chen et autres

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Association of HLA-G and HLA-F with recurrent miscarriage and implantation failure: a systematic review and meta-analysis

Nana Han, Wanting Xia, Can Zhu, Xuan Zhang et autres

implantation failure: a systematic review and metaanalysis.

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