Adriana Fontes

Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents

Jonas Engler, Eun‐Jung Kim, Dasol Kim, Noreene M. Shibata et autres

In Wilson disease (WD), excess copper provokes hepatocyte death due to impaired copper excretion, ultimately causing either acute or chronic liver damage. Current therapeutic compounds fail to reduce hepatic copper near to physiological levels, leaving lifelong, several times daily treatment as the …

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Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology

Amanda Caceres, Noreene M. Shibata, Christian D Davalos-Gutierrez, Gaurav V. Sarode et autres

The clinical manifestations of Wilson disease (WD) are related to copper accumulation in the liver and brain, but little is known about the role of other organs expressing the ATP7B copper transporter on metabolic and ultrastructural changes characterizing WD. To examine the …

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Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler et autres

Essential transition metals have key roles in oxygen transport, neurotransmitter synthesis, nucleic acid repair, cellular structure maintenance and stability, oxidative phosphorylation, and metabolism. The balance between metal deficiency and excess is typically ensured by several extracellular and intracellular mechanisms involved in uptake, …

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Copper impairs the intestinal barrier integrity in Wilson disease

Adriana Fontes, Hannah E. Pierson, Joanna B. Bierła, Carola Eberhagen et autres

In Wilson disease (WD), liver copper (Cu) excess, caused by mutations in the ATPase Cu transporting beta (ATP7B), has been extensively studied. In contrast, in the gastrointestinal tract, responsible for dietary Cu uptake, ATP7B malfunction is poorly explored. We therefore investigated gut …

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Mushrooms on the plate: Trends towards NAFLD treatment, health improvement and sustainable diets

Adriana Fontes, João Ramalho‐Santos, Hans Zischka, Anabela Marisa Azul

Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions …

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Isolation and Purification of Mitochondria from Cell Culture for Proteomic Analyses

Yaschar Kabiri, Christine von Toerne, Adriana Fontes, Percy Alexander Knolle et autres

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Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease

Adriana Fontes, Mireia Alemany i Pagès, Paulo J. Oliveira, João Ramalho‐Santos et autres

Mitochondria play a central role in non-alcoholic fatty liver disease (NAFLD) progression and in the control of cell death signalling during the progression to hepatocellular carcinoma (HCC). Associated with the metabolic syndrome, NAFLD is mostly driven by insulin-resistant white adipose tissue lipolysis …

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Mitochondria in non-alcoholic fatty liver disease

Inês C. M. Simões, Adriana Fontes, Paolo Pinton, Hans Zischka et autres

NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis and to end-stage liver disease. The molecular mechanisms that cause the progression of steatosis to severe liver damage are not fully understood. One suggested mechanism involves the oxidation …

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5F-PB-22 and XLR-11, two consumed synthetic cannabinoids, present a distinct toxicity profile in neuronal, hepatic and cardiac cells

Ana Santos-Carvalho, Adriana Fontes, Nayara Gomes Lima Santos, Ana Margarida Araújo et autres

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Platinum(II) complexes with carbazates and hydrazides: Synthesis, spectral characterization, computational modeling, and biological studies

Mariana Rodrigues, Ivana M. Marzano, Gabriel Henrique Ribeiro, Legna Colina–Vegas et autres

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Platinum(II) and palladium(II) aryl-thiosemicarbazone complexes: synthesis, characterization, molecular modeling, cytotoxicity, and antimicrobial activity

Tatiane Teixeira Tavares, Diego Fernando da Silva Paschoal, E.V.S. Motta, Arthur Girardi Carpanez et autres

Platinum(II) and palladium(II) complexes [ML2] have been isolated from reaction of K2PtCl4 or K2PdCl4 and ligands (L) derived from thiosemicarbazones. The complexes were characterized by elemental analysis, Raman, IR, and NMR spectroscopy. In addition, quantum mechanical calculations were used to predict their …

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Trypanocidal activity of lipophilic diamines and amino alcohols

Celso de Oliveira Rezende Júnior, Rosana O. Alves, Carlos A. M. Rezende, Cristiane França da Costa et autres

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