A. Jauch

Neocarzilin A induces apoptosis and mitochondrial disturbance by targeting reticulon 4-mediated endoplasmic reticulum stress

A. Jauch, Judith Sailer, Jessica L. Braun, Elena Czeslik et autres

Natural compounds are a valuable source of highly active biomolecules for the discovery of innovative drug targets as well as drug leads. The natural compound neocarzilin A (NCA) exhibits pronounced antiproliferative and antimigratory activity, which we previously ascribed to the target proteins …

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Chemische Proteomik enthüllt menschliche Off‐Targets der durch Fluorchinolone induzierten mitochondrialen Toxizität

Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres

Abstract Fluorchinolone (FQs) sind eine wichtige Klasse potenter Breitbandantibiotika. Ihre allgemeine Verwendung wird jedoch zunehmend durch unerwünschte Nebenwirkungen eingeschränkt. Während allgemeine Mechanismen für die Fluorchinolon‐assoziierte Behinderung (FQAD) identifiziert wurden, sind die zugrundeliegenden molekularen Ziele der Toxizität nach wie vor schwer fassbar. In …

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Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity

Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

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Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Till Reinhardt, Nina C. Bach, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

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Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity

Till Reinhardt, Nina C. Bach, Robin Alexander Rothemann, A. Jauch et autres

Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …

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Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Adriana Fontes, A. Jauch, Judith Sailer, Jonas Engler et autres

Essential transition metals have key roles in oxygen transport, neurotransmitter synthesis, nucleic acid repair, cellular structure maintenance and stability, oxidative phosphorylation, and metabolism. The balance between metal deficiency and excess is typically ensured by several extracellular and intracellular mechanisms involved in uptake, …

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Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR

Josef Braun, Yudong Hu, A. Jauch, Thomas F. Gronauer et autres

Neocarzilin (NCA) is a natural product exhibiting potent antimigratory as well as antiproliferative effects. While vesicle amine transport protein 1 (VAT-1) was previously shown to inhibit migration upon NCA binding, the molecular mechanisms responsible for impaired proliferation remained elusive. We here introduce …

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A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress

Anchel De Jaime-Soguero, Janina Hattemer, Albert Haas, Anja Bufe et autres

Abstract The development and homeostasis of organisms rely on the correct replication, maintenance and segregation of their genetic blueprints. How these intracellular processes are monitored across generations of different human cellular lineages, and why the spatio-temporal distribution of mosaicism varies during development …

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S123: DECODING TRANSCRIPTOMIC AND EPIGENETIC CONSEQUENCES OF STRUCTURAL VARIANTS IN CK-AML AT SINGLE-CELL RESOLUTION

Aino‐Maija Leppä, K. Grimes, Hyobin Jeong, Tobias Boch et autres

Background: Acute myeloid leukemia (AML) with complex karyotype (CK) is a heterogenous AML subgroup with dismal response to standard treatment. CK-AML has remained poorly characterized at the molecular level, with mainstream techniques struggling to unravel the complexity of the structural variants (SVs) …

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PF545 EASIX FOR PREDICTION OF SURVIVAL IN LOWER RISK MYELODYSPLASTIC SYNDROMES

Almuth Maria Anni Merz, Ulrich Germing, Guido Kobbe, A. Jauch et autres

Background: Patients with myelodysplastic syndromes (MDS) are at risk of early death from cardiovascular complications due to the link between clonal hematopoiesis and endothelial dysfunction. EASIX (Endothelial Activation and Stress Index) is a novel marker of endothelial dysfunction that is calculated from …

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EASIX FOR PREDICTION OF SURVIVAL IN LOWER RISK MYELODYSPLASTIC SYNDROMES

Almuth Maria Anni Merz, Ulrich Germing, Guido Kobbe, A. Jauch et autres

PF597 HIGH DOSE MELPHALAN (200MG/M2) AND AUTOLOGOUS TRANSPLANTATION IN NEWLY‐DIAGNOSED MULTIPLE MYELOMA UP TO THE AGE OF 70 YEARS: A SUBGROUP ANALYSIS FROM THE PHASE III GMMG‐MM5 TRIAL

E.K. Mai, Kaya Miah, Maximilian Merz, Jan Dürig et autres

Background: Analyses from prospective trials applying upfront high dose melphalan (200 mg/m2, HDM) and autologous blood stem cell transplantation (ASCT) up to 70 years (yrs) of age in the era of novel agents are rare. Aims: The multicenter, phase III GMMG‐MM5 trial …

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