Dasol Kim

Objective motor function assessment using diffusion tensor tractography in subacute acquired brain injury: A retrospective observational study

Au-Jin Wang, Choong-Hee Roh, Myoung-Hwan Ko, Dasol Kim et autres

Corticospinal tract (CST) integrity is a key determinant of motor recovery after focal brain injury. Diffusion tensor tractography (DTT) can quantify CST microstructural integrity, but clinically applicable thresholds predicting tract integrity to motor function remain unclear. This study aimed to evaluate whether …

kr (code pays fourni par la source)

Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents

Jonas Engler, Eun‐Jung Kim, Dasol Kim, Noreene M. Shibata et autres

In Wilson disease (WD), excess copper provokes hepatocyte death due to impaired copper excretion, ultimately causing either acute or chronic liver damage. Current therapeutic compounds fail to reduce hepatic copper near to physiological levels, leaving lifelong, several times daily treatment as the …

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Immunoglobulin G4-related spinal pachymeningitis: A case report

Tae-Seok Chae, Dasol Kim, Gi-Wook Kim, Yu Hui Won et autres

BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) is a complex immune-mediated condition that causes fibrotic inflammation in several organs. A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis, which manifests as inflammation of the dura mater in intracranial or spinal regions. Although IgG4-RD can …

kr (code pays fourni par la source)

Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis

Beomgu Lee, Jong Seong Roh, Hoim Jeong, Ye-Rin Kim et autres

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by skin and internal organ fibrosis and obliterative vasculopathy. Few effective treatments are currently available for fibrosis in SSc, therefore, demand persists for novel therapies. Although use of Ginkgo biloba extract (GBE) has …

kr, us (code pays fourni par la source)

Virological characteristics and the rapid antigen test as deisolation criteria in immunocompromised patients with COVID‐19: A prospective cohort study

Sung‐Woon Kang, Jun‐Won Kim, Ji Yeun Kim, So Yun Lim et autres

There are limited data supporting current Centers for Disease Control and Prevention guidelines for the isolation period in moderate to severely immunocompromised patients with coronavirus disease 2019 (COVID-19). Adult COVID-19 patients who underwent solid organ transplantation (SOT) or received active chemotherapy against …

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ARBM-101 as an emerging potent therapeutic option for Wilson disease

Banu Akdogan, Eun‐Jung Kim, Emilie Munk, Dasol Kim et autres

ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats

Claudia Einer, Ditte Emilie Munk, Eok Park, Banu Akdogan et autres

BACKGROUND & AIMS: Excess copper causes hepatocyte death in hereditary Wilson's disease (WD). Current WD treatments by copper-binding chelators may gradually reduce copper overload; they fail, however, to bring hepatic copper close to normal physiological levels. Consequently, lifelong daily dose regimens are …

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Application of periostin peptide-decorated self-assembled protein cage nanoparticles for therapeutic angiogenesis

Ba Reun Kim, Jung Won Yoon, Hyukjun Choi, Dasol Kim et autres

Peptides are gaining substantial attention as therapeutics for human diseases. However, they have limitations such as low bioavailability and poor pharmacokinetics. Periostin, a matricellular protein, can stimulate the repair of ischemic tissues by promoting angiogenesis. We have previously reported that a novel …

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Mitochondrial ROS Produced in Human Colon Carcinoma Associated with Cell Survival via Autophagy

Eun Gwak, Dasol Kim, Hui-Yun Hwang, Ho Jeong Kwon

Human colon carcinomas, including HCT116 cells, often exhibit high autophagic flux under nutrient deprivation or hypoxic conditions. Mitochondrial ROS (mROS) is known as a ‘molecular switch’ for regulating the autophagic pathway, which is critical for directing cancer cell survival or death. In …

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Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction

Ye Seul Kim, Jung Won Yoon, Dasol Kim, Seung‐Hak Choi et autres

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulates the maturation of hESC-CMs. Treatment of …

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Mitochondrial ROS Produced in Human Colon Carcinoma HCT116 Cells Reduces Cell Survival via Autophagy

Eunji Gwak, Dasol Kim, Hui-Yun Hwang, Ho Jeong Kwon

Human colon carcinomas, including HCT116 cells, often exhibit high basal autophagic flux under nutrient deprivation or hypoxic conditions. Mitochondrial ROS (mROS) is known as a “molecular switch”’ for regulating the autophagic pathway, which is critical for directing cancer cell survival or death. …

kr (code pays fourni par la source)

Natural Herb Mixture Extract Accelerates Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Activating the SMAD Pathway.

Kwang-Soo Koh, Tae‐Young Kim, Yeon-Ju Kwak, Hyung Joon Kim et autres

We aimed to analyze the effects and explore the molecular mechanisms of a natural herb mixture extract (NME) on osteoblasts during differentiation in human bone marrow-derived mesenchymal stem cells (hBMSCs). We tried to confirm the regulation of osteogenic differentiation during NME treatment. …

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