Jichen Li

Characterization of a Sabin-like type 2/3 recombinant poliovirus with a triple nucleotide deletion in the VP1 region isolated from sewage

Jie Lin, Chenglin Zhu, Jichen Li, Wei Zhang et autres

Nucleotide (nt) deletions in the VP1 region of poliovirus are extremely rare. However, as early as 2012, we detected a natural type 2 poliovirus strain in sewage, originating from the Sabin 2, which exhibited such deletions. Whole-genome analysis revealed that the virus …

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Spinal Cord Injury in Enterovirus D68 Infection: Mechanisms and Pathophysiology in a Mouse Model

Wei Duan, Jichen Li, Ying Liu, Rui Chen Wang et autres

Enterovirus D68 (EV-D68) is a significant global pathogen associated with severe respiratory infections and acute flaccid myelitis in children. Currently, there are no vaccines or antiviral drugs available for EV-D68, and a robust model to elucidate the pathogenesis of EV-D68 and evaluate …

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ARFGAP1 serves as a critical host factor during E30 infection: QS11 inhibits viral pathogenesis in hFcRn-IFNAR−/− mice

Jichen Li, Wei Duan, Ying Liu, Rui Chen Wang et autres

Echovirus 30 (E30) is a positive-sense RNA virus in the Picornaviridae family, specifically within the Enterovirus genu. It is a known pathogen that causes severe infectious diseases in humans. However, mechanisms underlying viral infection remain poorly understood. Therefore, this study aims to …

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Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions

Yong Zhang, Wanling Zheng, Rufei Dai, Tianyi Ma et autres

To investigate the mechanism underlying chronic jet lag (CJL)-induced circadian disruption stimulating glioma-related gene expression across distinct brain regions, and to examine the regulatory role of core clock genes in modulating neural oncogenic susceptibility. This experiment was initiated with the establishment of …

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Pathological characteristics of a murine oral coxsackievirus A10 infection model

Jichen Li, Tianjiao Ji, Qian Yang, Guoyan Zhang et autres

Coxsackievirus A10 (CVA10) is an enterovirus that has caused global outbreaks of hand, foot, and mouth disease (HFMD), accompanied by neurological and systemic complications. Animal models that can simulate natural infections are necessary for studying viral pathogenesis. In this study, our objective …

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The Immunogenicity of Coxsackievirus A6 (D3a Sub‐Genotype) Virus‐Like Particle and mRNA Vaccines

Huanhuan Lu, Jinbo Xiao, Jingdong Song, Yang Song et autres

ABSTRACT In recent years, coxsackievirus A6 (CVA6) has surpassed enterovirus A71 to become the main pathogen causing severe Hand, Foot, and Mouth disease (HFMD) in China with a substantial disease burden. However, there is currently no commercial CVA6 vaccine. The D3a genotype …

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Cover Image, Volume 97, Number 2, February 2025

Huanhuan Lu, Jinbo Xiao, Jingdong Song, Yang Song et autres

Front Cover Caption: The cover image is based on the article The Immunogenicity of Coxsackievirus A6 (D3a Sub-Genotype) Virus-Like Particle and mRNA Vaccines by Yong Zhang et al., https://doi.org/10.1002/jmv.70201.

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Epidemiology of Hand, Foot, and Mouth Disease and Genetic Characterization of Coxsackievirus A16 in Shenyang, Liaoning Province, China, 2013–2023

Fan Li, Jinbo Xiao, Huijie Chen, Ling Chen et autres

Hand, foot, and mouth disease (HFMD), a common childhood infection caused by enterovirus, poses a serious public health concern in China. We collected and analyzed epidemiological data on 62,133 HFMD cases in Shenyang City, Liaoning Province, from 2013 to 2023. The average …

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Efficacy and safety of tetrandrine in treatment of rheumatoid arthritis: a meta-analysis

Juan Xu, Jichen Li, Ye Yan, Qingwei David Zhao et autres

Objective To explore the efficacy and safety of tetrandrine in the treatment of rheumatoid arthritis. Methods Randomized controlled studies of tetrandrine in the treatment of rheumatoid arthritis were searched in CNKI, VIP, Wanfang database, SinoMed, PubMed, Springer, Web of Science and Cochrane …

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Inflammatory damage caused by Echovirus 30 in the suckling mouse brain and HMC3 cells

Jichen Li, Yanjun Zong, Tiantian Sun, Ying Liu et autres

Echovirus 30 (E30), a member of the species B Enterovirus family, is a primary pathogen responsible for aseptic meningitis and encephalitis. E30 is associated with severe nervous system diseases and is a primary cause of child illness, disability, and even mortality. However, …

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Evolution, recombination and geographic spreading of global Coxsackievirus A6

Huanhuan Lu, Jinbo Xiao, Yang Song, Dongmei Yan et autres

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Identification and genetic characterization of a recently identified enterovirus C116 in China

Zhenzhi Han, Jichen Li, Jinbo Xiao, Huanhuan Lu et autres

Enterovirus C116 (EV-C116) is a new member of the enterovirus C group which is closely associated with several infectious diseases. Although sporadic studies have detected EV-C116 in clinical samples worldwide, there is currently limited information available. In this study, two EV-C-positive fecal …

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