Dongmei Yan

High-throughput sequencing reveals the virome characteristics of wastewater in Gansu Province, China from 2024 to 2026

Yabei Xu, Xiaohong Zhao, Shang Gao, Jinbo Xiao et autres

Emerging and re-emerging infectious diseases continue to pose a persistent challenge to global public health security. As an unbiased and noninvasive population-level surveillance approach, wastewater-based epidemiology has emerged as an urban-scale monitoring tool for proactively capturing the community disease burden. In this …

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Genotype-phenotypic correlation in a Chinese patient with isolated lissencephaly sequence caused by 17p13.3p13.2 chromosomal microdeletion: a 6-year follow-up study

Jiao Tong, Xu Chen, Tao Wang, Shan Ma et autres

Background Isolated lissencephaly sequence (ILS) is a severe neurodevelopmental disorder associated with 17p13.3 microdeletion. This 6-year longitudinal study aimed to systematically characterize physical and neurodevelopmental trajectories of a Chinese ILS patient and offer evidence for early diagnosis and clinical intervention. Methods From …

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In vitro regeneration via indirect organogenesis from aseptic seedling-derived explants of the rare Tibetan medicinal shrub Sibiraea angustata

Mengting Pi, Xue Yu, Hui Li, Yali Guo et autres

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Factors Associated with Pregnancy Stress in High-Risk Pregnant Women Before Invasive Prenatal Diagnosis: A Cross-Sectional Study

Xu Chen, Yali Zhao, Qingqing Gu, Zhiwei Wang et autres

Purpose: Pregnant women often experience pregnancy stress, which negatively impacts maternal and fetal health. Studies on pregnancy stress in high-risk pregnancies are limited. This study aimed to investigate pregnancy stress in high-risk pregnant women before invasive prenatal diagnosis and analyze factors associated …

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Lactobacillus johnsonii mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα–SCD1 axis

Yan Cheng, Wu Z, Ruoyue Huang, Qi Li et autres

Ulcerative colitis (UC) is a systemic disease that can involve multiple organs, and hepatobiliary diseases in UC patients are frequently observed. However, the pathogenesis of UC and its associated hepatobiliary complications remains elusive, and limited therapeutic options are available. This study revealed …

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The Factors Associated with the Health-Related Quality of Life in Pregnant Women in the second and Third Trimesters: Evidence from Jiangsu Province, Eastern China

Lianshuai Zheng, Xu Chen, Yao Meng, Zhongwu Hu et autres

Purpose: The health-related quality of life (HRQoL) of pregnant women has received much attention. Understanding the factors affecting their HRQoL will help health care providers develop targeted strategies for pregnancy care. This study investigated the current status of pregnant women’s HRQoL in …

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Pathological characteristics of coxsackievirus A14 in neonatal mice model

Liheng Yu, J H Li, Hongbing Lu, Ying Liu et autres

In recent years, with the increasing incidence of other non-EV-A71 enteroviruses, the research on other enteroviruses has become more and more important. Coxsackievirus A14 (CVA14), A member of the enterovirus group A, causes hand-foot-mouth disease (HFMD), aseptic meningitis and acute abdominal pain. …

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Prevalence and influencing factors of workplace violence among doctors in Northeast China: a cross-sectional study

Xu Chen, Y. Zhang, Jun Qin, Yu Wang et autres

Workplace violence (WPV) against healthcare workers has become a growing problem, which seriously affects the medical service market and is the focus of global concern. This study aimed to evaluate the prevalence of WPV among doctors in tertiary general hospitals in Northeast …

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Characterization of a Sabin-like type 2/3 recombinant poliovirus with a triple nucleotide deletion in the VP1 region isolated from sewage

Jie Lin, Chenglin Zhu, Jichen Li, Wei Zhang et autres

Nucleotide (nt) deletions in the VP1 region of poliovirus are extremely rare. However, as early as 2012, we detected a natural type 2 poliovirus strain in sewage, originating from the Sabin 2, which exhibited such deletions. Whole-genome analysis revealed that the virus …

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Significant ocular residual astigmatism reduces the effect of orthokeratology lenses in controlling myopia

Jian Lin, Dexiang An, Yun Lu, Dongmei Yan

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Comparison of ocular residual astigmatism between children with clinically significant and non-significant astigmatism

Jian Lin, Dexiang An, Jun Zhu, Dongmei Yan

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Factors related to quality of life in caregivers of children with autism spectrum disorder: emphasizing challenges in the context of Eastern China

Xu Chen, Tong Jiao, Xue Wang, Lu Zhu et autres

BACKGROUND: Caregivers of children with autism spectrum disorder (ASD) encounter multiple challenges, increasing their risk of experiencing a low quality of life (QOL). Therefore, this study aims to examine the QOL among caregivers of children with ASD in eastern China and to …

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