Identification and genetic characterization of a recently identified enterovirus C116 in China
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Le résumé fourni par la source
Enterovirus C116 (EV-C116) is a new member of the enterovirus C group which is closely associated with several infectious diseases. Although sporadic studies have detected EV-C116 in clinical samples worldwide, there is currently limited information available. In this study, two EV-C-positive fecal specimens were detected in apparently healthy children, which harbored low abundance, through meta-transcriptome sequencing. Based on the prototypes of several EV-Cs, two lineages were observed. Lineage 1 included many types that could not cause EV-like cytopathic effect in cell culture. Three genogroups of EV-C116 were divided in the maximum likelihood tree, and the two strains in this study (XZ2 and XZ113) formed two different lineages, suggesting that EV-C116 still diffuses worldwide. Obvious inter-type recombination events were observed in the XZ2 strain, with CVA22 identified as a minor donor. However, another strain (XZ113) underwent different recombination situations, highlighting the importance of recombination in the formation of EV-Cs biodiversity. The EV-C116 strains could propagate in rhabdomyosarcoma cell cultures at low titer; however, EV-like cytopathic effects were not observed. HEp-2, L20B, VERO, and 293T cell lines did not provide an appropriate environment for EV-C116 growth. These results challenge the traditional recognition of the uncultured nature of EV-C116 strains and explain the difficulty of clinical detection.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Identification and genetic characterization of a recently identified enterovirus C116 in China
- Date Crossref
- 01/03/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Institute of Pediatrics pays non établi dans la noticeStructure de recherche
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National Institute for Viral Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Tibet Autonomous Region People's Hospital pays non établi dans la noticeÉtablissement de santé
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Laboratory of Virology pays non établi dans la noticeStructure de recherche
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National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) pays non établi dans la noticeStructure de recherche
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WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Biosafety pays non établi dans la noticeStructure de recherche
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Tibet Center for Disease Control and Prevention Lhasa City Tibet Autonomous Region China pays non établi dans la noticeInstitution
Capital Institute of Pediatrics, National Institute for Viral Disease Control and Prevention et Tibet Autonomous Region People's Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.