Soon-Cen Huang

Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway

Yi‐Hui Wu, Pei-Ying Wu, Yu-Fang Huang, Chien‐Chin Chen et autres

Biomarkers that predict disease progression may assist in the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. This study aimed to investigate the role of collagen type IV alpha 6 (COL4A6) in cell invasiveness, tumor formation, chemoresistance, and …

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COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells

Yi‐Hui Wu, Yu-Fang Huang, Tzu‐Hao Chang, Chien‐Chin Chen et autres

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Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi‐Shyun Lai et autres

Abstract Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Formation and disassembly of focal adhesions are regulated dynamically during cell migration, …

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Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Wen‐Tai Chiu, Heng-Ai Chang, Yi-Hsin Lin, Yu-Shan Lin et autres

Abstract Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2 on Ca2+ levels remains controversial. Store-operated …

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Revealing the three dimensional architecture of focal adhesion components to explain Ca2+-mediated turnover of focal adhesions

Shu-Jing Chang, Ying‐Chi Chen, Chi-Hsun Yang, Soon-Cen Huang et autres

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FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells

Wen‐Tai Chiu, Yu-Fang Huang, Huei-Yu Tsai, Chien‐Chin Chen et autres

// Wen-Tai Chiu 1,2 , Yu-Fang Huang 3 , Huei-Yu Tsai 4 , Chien-Chin Chen 5,6 , Chang-Hwa Chang 2 , Soon-Cen Huang 7 , Keng-Fu Hsu 3,4 and Cheng-Yang Chou 3,4 1 Department of Biomedical Engineering, National Cheng Kung University, Tainan, …

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Enhanced myometrial autophagy in postpartum uterine involution

Keng‐Fu Hsu, Hsien‐An Pan, Yu‐Yun Hsu, Ching-Ming Wu et autres

OBJECTIVE: To understand the mechanisms of postpartum uterine involution, we investigated the uterine myometrial changes during pregnancy and the postpartum period. MATERIALS AND METHODS: Nine groups of uterine myometrial samples from mice (n = 4) were collected on gestational Day 0 (nonpregnant), …

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Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX

Chi‐Long Chen, Jan‐Show Chu, Wu‐Chou Su, Soon-Cen Huang et autres

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Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

Keng‐Fu Hsu, Chao‐Liang Wu, Soon-Cen Huang, Ching-Ming Wu et autres

Cathepsins have long been considered as housekeeping molecules. However, specific functions have also been attributed to each of these lysosomal proteases. Squamous cell carcinoma antigen (SCCA) 1, widely expressed in various uterine cervical cells, is an endogenous cathepsin (cat) L inhibitor. In …

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Roles for hypoxia-regulated genes during cervical carcinogenesis: Somatic evolution during the hypoxia–glycolysis–acidosis sequence

Wen‐Ying Lee, Soon-Cen Huang, Keng‐Fu Hsu, Ching‐Cherng Tzeng et autres

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Alterations of Metastasis-Related Genes Identified Using an Oligonucleotide Microarray of Genistein-Treated HCC1395 Breast Cancer Cells

Wen‐Ying Lee, Soon-Cen Huang, Ching‐Cherng Tzeng, Tsui-Ling Chang et autres

Genistein, one of the major isoflavones, potently inhibits the growth and metastasis of breast cancer. However, the precise molecular mechanism in metastasis inhibition is not clear. We investigated the effect of genistein in HCC1395 cells, a cell line derived from an early-stage …

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Enhanced Polyadenosine Diphosphate-Ribosylation in Gonadotropin-Releasing Hormone Agonist-Treated Uterine Leiomyoma

Soon-Cen Huang, Ming‐Jer Tang, Ya-Min Cheng, Keng‐Fu Hsu et autres

This study aimed to examine the activation of poly(ADP-ribose) polymerase (PARP) and the accumulation of its end product, poly(ADP-ribose) (PAR), in uterine leiomyoma specimens obtained from 25 patients receiving Leuplin depot [leuprorelin acetate, depot (LA)] treatment and 46 control patients and explore …

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