Heng-Ai Chang

Sex differences in cocaine-associated memory: The interplay between CB1, mGluR5, and estradiol

Heng-Ai Chang, Wen Dai, Sherry Shu‐Jung Hu

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Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions

Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi‐Shyun Lai et autres

Abstract Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Formation and disassembly of focal adhesions are regulated dynamically during cell migration, …

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Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Yu‐Min Lin, Hung-Yu Sun, Wen‐Tai Chiu, Hui-Chen Su et autres

Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as …

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STIM1 Knockout Enhances PDGF-Mediated Ca2+ Signaling through Upregulation of the PDGFR–PLCγ–STIM2 Cascade

Tzu-Yu Huang, Yi-Hsin Lin, Heng-Ai Chang, Tzu-Ying Yeh et autres

Platelet-derived growth factor (PDGF) has mitogenic and chemotactic effects on fibroblasts. An increase in intracellular Ca2+ is one of the first events that occurs following the stimulation of PDGF receptors (PDGFRs). PDGF activates Ca2+ elevation by activating the phospholipase C gamma (PLCγ)-signaling …

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Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Wen‐Tai Chiu, Heng-Ai Chang, Yi-Hsin Lin, Yu-Shan Lin et autres

Abstract Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2 on Ca2+ levels remains controversial. Store-operated …

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Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Ying‐Chi Chen, Yu-Chung Chang, Heng-Ai Chang, Yu-Shan Lin et autres

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