Chao‐Liang Wu

A novel, non-spirometric “BMP index” for predicting severe adverse outcomes in fibrosing interstitial lung diseases

Tang‐Hsiu Huang, Hsin-Yu Hou, Han-Yu Chang, Chengping Hu et autres

Abstract Fibrosing interstitial lung diseases (fILDs) exhibit diverse clinical courses and prognoses, with no established biomarkers for predicting acute exacerbation (AE) and early death. This study introduces a novel composite “BMP index”, integrating body mass index (BMI), mucin-1, and pentraxin 3 (PTX3) …

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Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria

Bo Xing, Cong Liu, Wantong Chen, Zhuoran Li et autres

The scarcity of cultivated gut bacteriophages hinders gut microbial research and application. Here we report the establishment and characterization of a Gut Phage Biobank (GPB) ( https://db.cngb.org/genomics/datasets/GDS0000055 ) through a systematic isolation workflow and containing 104 isolates that target abundant or disease-associated …

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SIRT1/PGC-1α/Mfn2 pathway regulates mitochondrial homeostasis in VSMC to attenuate aging-related vascular calcification

Chao‐Liang Wu, Zufei Wu, Long Hu, Long Tang et autres

Aging-related vascular calcification is closely associated with the development and progression of arterial diseases in elderly patients. Studies have shown that mitochondrial fusion/fission imbalance plays a crucial role in the formation of aging-related vascular calcification, and upregulation of silent information regulator 1 …

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OCT4-mediated upregulation of DUSP6 promotes metastasis in non-small-cell lung cancer

Bing‐Hua Su, Chung-Teng Wang, Chia-Sing Lu, Tang‐Hsiu Huang et autres

The roles of cancer stem cells and Octamer-binding transcription factor 4 (OCT4) have been implicated in human tumorigenesis and metastasis.However, the role of OCT4 in the metastasis of non-small-cell lung cancer (NSCLC) remains undetermined, especially regarding stem cell-related pathways.Previous research has reported …

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Global Burden of Disease of interstitial lung disease and pulmonary sarcoidosis in adolescents and young adults (1990–2019), and projections for the next 30 years

Xiaoshuang He, Lu Wang, Zhao Yu, Yuanyuan Qu et autres

BACKGROUND: Interstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases that are difficult to diagnose and costly to treat. Adolescents and young adults (AYAs) aged 15-39 years are frequently overlooked in global burden estimates despite their unique epidemiological and societal …

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[Monomorphic epitheliotropic intestinal T-cell lymphoma: a clinicopathological and genetic mutation characteristics analysis of forty-two cases].

Dage Fan, Y Z Wang, A Q Li, Bo Ouyang et autres

MEITL is a rare and highly aggressive peripheral T-cell lymphoma. Its clinical manifestations are diverse, and diagnosis primarily relies on a comprehensive assessment of pathological morphology, immunohistochemical profiles, and EBV infection status, supplemented by genetic testing if necessary. At present, there is …

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Galectin-1-conjugated gold nanoparticles as a multivalent macromolecular platform for broad-spectrum inhibition of influenza virus via glycan recognition

Mei‐Lin Yang, Nai-Chi Yeh, Chao‐Liang Wu, Ai‐Li Shiau et autres

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Impact of extrusion moisture and temperature on digestibility of barramundi (Lates calcarifer) diets containing bacterial protein meal

Richard Le Boucher, William Chung, C.S. Lee, Chao‐Liang Wu et autres

Bacterial protein meals (BPMs) are emerging as promising alternatives to conventional protein sources in aquafeeds. However, clear limitations have also been evidenced regarding the high inclusion rate of BPMs in aquafeed. This study investigates how feed extrusion settings can improve digestibility of …

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Letter to the Editor: Development of a prognostic immune cell-based model for ovarian cancer using multiplex immunofluorescence

Chao‐Liang Wu, Yuhang Liu, Jiaao Sun, Chi Ma

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Sophora flavescens-derived extracellular vesicles loaded with oncolytic vaccinia virus/IR1061 for NIR-II photoacoustic imaging guided multimodal treatment of diffuse large B-cell lymphoma

Lichen Ji, Jiaqing Huang, Yehui Kang, Chao‐Liang Wu et autres

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, characterized by high heterogeneity and significant clinical challenges. Despite the widespread adoption of the R-CHOP regimen as the standard treatment, approximately 30 %-40 % of patients experience relapse, necessitating …

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Assessing the global burden of interstitial lung disease and pulmonary sarcoidosis using multiple statistical models: analysis and future projections

Luna Zhao, Yue Zhou, Jia Yun, Lang Wang et autres

BACKGROUND: Interstitial lung disease (ILD) and pulmonary sarcoidosis (PS) constitute major global health challenges, characterized by progressive respiratory symptoms and diverse epidemiological trends. Although the incidence and mortality rates of ILD and PS have increased following the COVID-19 pandemic, comprehensive research examining …

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0604 Akkermansia muciniphila ameliorates imiquimod-induced skin thickening, colitis, and gut microbiota alterations: A metagenome association study

Yang Chen, Hsiu J. Ho, Chao‐Liang Wu