Chi‐Long Chen

Key challenges in communication across milestones of cancer care continuum: a systematic review

Viet Cuong Nguyen, Khoa Tran, Do-Quyen Thi Phan, Nguyen-Tuong Pham et autres

BACKGROUND: Effective communication is essential in cancer care, significantly influencing patients' emotional, psychological, and physical outcomes. As patients' needs and goals evolve across different stages of the cancer journey, communication barriers also change. This systematic review aimed to identify key communication barriers …

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Fibronectin 1 mediates pressure-induced aggressive phenotypes in colorectal cancer cells and cancer stem cells

Viet Cuong Nguyen, Kuang-Chao Cheng, Thuy-Tien Thi Phan, Thi-Luu Ho et autres

BACKGROUND: Multiple interacting factors within the tumor microenvironment, including mechanical pressure, extracellular matrix components, hypoxia, and vascular architecture, are known to promote cancer progression. Although fibronectin 1 functions as a critical extracellular matrix glycoprotein in colorectal cancer, its specific interaction with mechanical …

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Correction for: miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei‐Ting Chang, Jhih‐Yuan Shih, Yu‐Wen Lin, Tzu-Ling Huang et autres

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Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stress

Yi‐Fang Yang, Zhao-Jing He, Yu-Yu Lin, Cheorl‐Ho Kim et autres

Estrogen receptor-positive (ER⁺) breast cancer is commonly treated with hormone therapy; however, these tumors frequently develop drug resistance and exhibit poor responses to radiotherapy. To investigate the molecular basis of therapy resistance, we explored the role of estrogen receptor alpha (ESR1) in …

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Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

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Abstract A048: Weakly supervised prediction of EGFR mutation status and early metastasis of lung adenocarcinoma whole slide histopathology images using artificial intelligence

Chi‐Long Chen, Chi‐Chung Chen, Tzu-Hao Chang, Ming-Shu Hsieh et autres

Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Adenocarcinoma is the most common histological subtype, followed by squamous cell carcinoma. Treatment of lung cancer depends on clinical stage and pathological types. Current guidelines for lung adenocarcinoma recommend testing for …

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Nicotine‐driven enhancement of tumor malignancy in triple‐negative breast cancer via additive regulation of CHRNA9 and IGF1R

Yung‐Che Kuo, Chi‐Long Chen, Kha‐Liang Lee, Hsiao‐Feng Wang et autres

Cigarette smoking is a significant risk factor for cancer development with complex mechanisms. This study aims to investigate the impact of nicotine exposure on the regulation of stemness- and metastasis-related properties via cholinergic receptor nicotinic alpha 9 subunit (CHRNA9) and insulin-like growth …

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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

BACKGROUND: Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on …

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B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis

Tzu‐Hui Hsu, Yu‐Chan Chang, Yi-Yuan Lee, Chi‐Long Chen et autres

Transforming growth factor (TGF)-β signaling is critical for epithelial-mesenchymal transition (EMT) and colorectal cancer (CRC) metastasis. Disruption of Smad-depednent TGF-β signaling has been shown in CRC cells. However, TGF-β receptor remains expressed on CRC cells. Here, we investigated whether the cooperation between …

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PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression

Yu‐Chan Chang, Ming‐Hsien Chan, Chien‐Hsiu Li, Chi‐Long Chen et autres

Glioblastoma (GBM) is a type of brain cancer categorized as a high-grade glioma. GBM is characterized by limited treatment options, low patient survival rates, and abnormal serotonin metabolism. Previous studies have investigated the tumor suppressor function of aldolase C (ALDOC), a glycolytic …

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Abstract 3084: Aldob regulates fructose metabolism to confer ferroptosis and immune response in colorectal cancer harboring microsatellite instability

Yu‐Chan Chang, Chi‐Long Chen

Abstract Microsatellite instability (MSI) is a genetic alteration that occurs during cancer progression, specifically in colorectal cancer. Objective evidence demonstrates that colorectal cancer patients with MSI have better survival rates than those without MSI. Moreover, patients with both dMMR and MSI respond …

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Abstract 6517: ALDOC as an indicator of HMGB1 blockade combined with checkpoint inhibitor based immunotherapy in GBM patients

Yi‐Fang Yang, Ming‐Hsien Chan, Chi‐Long Chen, Michael Hsiao et autres

Abstract Aldolase is an enzyme that takes part in glycolysis by catalyzing a six-carbon intermediate to yield two three-carbon products, requiring ATP. The aldolase family comprises three members, namely ALDOA, ALDOB, and brain-specific ALDOC. Low-grade gliomas and glioblastoma (GBM) are characterized by …

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