Ying‐Chi Chen

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Ying‐Chi Chen, Li-Chan Chang, Yanling Liu, Ming‐Che Chang et autres

Cancer remains a global health challenge necessitating innovative therapies. We introduce a strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched with …

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Utilizing Electron‐Sink‐Enhanced Nanoshells for Amplified Nanoplasmonic SERS‐Based In Situ Detection of Cancer Cells, Linking Signal Enhancement with Cellular Damage

Liu‐Chun Wang, Yu‐Cheng Kuo, Yen‐Ting Kuo, K.C. Chang et autres

A novel method is presented for detecting cancer cells and assessing apoptosis using electron-sink-enhanced surface-enhanced Raman scattering (SERS) via active electron transfer. By coating gold (Au) shells with electroactive liposome membranes (ELMs) derived from Shewanella oneidensis MR-1, the SERS signal is enhanced …

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Efficient Weight Pruning for Optical Neural Networks: When Pruned Weights are Non-Zeros

Shuo Zhao, Kun Wu, Xin Li, Ying‐Chi Chen

Optical neural networks (ONNs) have emerged as a promising solution for energy-efficient deep learning. However, their resource-intensive manufacturing process necessitates efficient methods to streamline ONN architectures without sacrificing their performances. Weight pruning presents a potential remedy. Unlike the conventional neural networks, the …

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An integrated framework for accurate trajectory prediction based on deep learning

Shuo Zhao, Zhaozhi Li, Zikun Zhu, Charles Chang et autres

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Communication-Efficient Federated Learning for Decision Trees

Shuo Zhao, Zikun Zhu, Xin Li, Ying‐Chi Chen

The increasing concerns about data privacy and security have driven the emergence of federated learning, which preserves privacy by collaborative learning across multiple clients without sharing their raw data. In this article, we propose a communication-efficient federated learning algorithm for decision trees …

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Caveolin-1 differentially regulates the transforming growth factor-β and epidermal growth factor signaling pathways in MDCK cells

Shih‐Chuan Hsiao, Wei‐Hsiang Liao, Heng-Ai Chang, Yi‐Shyun Lai et autres

Caveolin-1 is critical for interacting with the TGF-β receptor (TGFβR) and EGF receptor (EGFR) signaling, often observed in advanced cancers and tissue fibrosis. However, the mechanism underlying caveolin-1-mediated transactivation of TGFβR and EGFR signaling remains unclear. Therefore, we sought to determine whether …

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Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics

Divinah Manoharan, Liu‐Chun Wang, Ying‐Chi Chen, Weipeng Li et autres

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such as high surface-to-volume ratio and unique optical, electric, and magnetic properties. The CNPs, based on their physio-chemical nature, can either increase the reactive oxygen species (ROS) level …

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Optogenetically engineered calcium oscillations promote autophagy-mediated cell death via AMPK activation

Yi‐Shyun Lai, Meng-Ru Hsieh, Thi My Hang Nguyen, Ying‐Chi Chen et autres

Autophagy is a double-edged sword for cells; it can lead to both cell survival and death. Calcium (Ca 2+ ) signalling plays a crucial role in regulating various cellular behaviours, including cell migration, proliferation and death. In this study, we investigated the …

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Author response for "Optogenetically engineered calcium oscillations promote autophagy-mediated cell death via AMPK activation"

Yi‐Shyun Lai, Meng-Ru Hsieh, Thi My Hang Nguyen, Ying‐Chi Chen et autres

High-voltage, CMOS-enabled, and silicon wire array decorated photovoltaic module for driving smart dimming glasses

Yung‐Jr Hung, Ying‐Chi Chen, Yi‐Chen Wu, Chung-Ming Yang

We demonstrate a miniaturized silicon photovoltaic (PV) module in standard bulk CMOS for driving smart dimming glasses. The PV is front-illuminated to leverage the high-lifetime silicon denuded zone and is decorated with silicon wire array to reduce the optical reflectivity at silicon/intermediate …

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Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Liu‐Chun Wang, Pei‐Yu Chiou, Ya-Ping Hsu, Chin‐Lai Lee et autres

Abstract Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian blue …

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Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Ying‐Chi Chen, Yiting Li, Chin‐Lai Lee, Yen-Ting Kuo et autres

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