Ling Shen

[Otitis media with effusion in children: research advances from microecological mechanisms to precision diagnosis and treatment].

Pingfan Liu, Ling Shen, Zongtong Lin, Xinzhong Gao

Otitis media with effusion（OME） is a prevalent otologic condition in children that may lead to persistent hearing impairment and speech-language developmental delays. Recent studies have demonstrated that nasopharyngeal-middle ear microecological dysbiosis plays a central role in OME pathogenesis and chronicity. Advances in …

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Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation

Jeffrey A. Klein, David James Taber, David Wojciechowski, Didier A. Mandelbrot et autres

KEY POINTS: We assessed whether an initial donor-derived cell-free DNA elevation during routine surveillance was associated with allograft dysfunction and loss in kidney transplant recipients. Intermediate and high donor-derived cell-free DNA states were independently associated with 3.7-fold and 6.4-fold higher risks of …

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Altered Regional Brain Activity Underlying the Higher Postoperative Analgesic Requirements in Abstinent Smokers: A Prospective Cohort Study

Kai Wei, Kunming Tao, Yanzhi Bi, Xuerong Miao et autres

Perioperative abstinent smokers experience heightened pain sensitivity and increased postoperative analgesic requirements, likely due to nicotine withdrawal-induced hyperalgesia. However, the underlying neural mechanisms in humans remain unclear. To address this issue, this study enrolled 60 male patients (30 abstinent smokers and 30 …

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Dd-cfDNA Predicts Long-Term Graft Outcomes: Kidney Allograft Outcomes AlloSure Registry (KOAR) Results

David Wojciechowski, Tarek Alhamad, Dhiren Kumar, Jeffrey Alan Klein et autres

Background: We evaluated the prognostic value of dd-cfDNA for graft dysfunction and graft loss in the Kidney Allograft Outcomes AlloSure Registry (KOAR NCT03326076). Methods: 1,743 kidney transplant recipients (KTR) from 56 U.S. centers were prospectively enrolled from 2018 to 2020. At the …

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Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies

Jonathan S. Bromberg, Daniel C. Brennan, MATTHEW M. COOPER, Enver Akalin et autres

Donor-derived cell-free DNA (dd-cfDNA) is a biomarker that enables the early detection of immune-mediated graft injury. This study evaluated the clinical utility of dd-cfDNA in predicting the presence of biopsy-proven rejection (BPAR). We analyzed 1070 biopsies from 1743 kidney transplant recipients enrolled …

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[Diagnosis and treatment of special type of laryngeal foreign body with granuloma in children].

Da-Hong Tu, Zongtong Lin, Ling Shen, Zhongjie Yang et autres

A special type of laryngeal foreign body with granuloma may lack of accurate foreign body history, resulting in long-term retention of foreign bodies, leading to granuloma formation and misdiagnosis. Electronic laryngoscopy combined with CT examination contribute to early diagnosis. Low temperature plasma …

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[New progress in diagnosis and treatment of congenital laryngomalacia in infants].

Pingfan Liu, Zongtong Lin, Ling Shen, Zhongjie Yang

Congenital laryngomalacia is the most common disease causing laryngeal stridor in infants. The pathogenesis has not yet been clearly concluded. It may be related to abnormal development of laryngeal cartilage anatomical structure, neuromuscular dysfunction, gastroesophageal and laryngeal reflux disease, etc. The typical …

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[Analysis of cases of laryngeal airway diseases in infants].

Qiaoyu Liao, Zongtong Lin, Ling Shen, Zhongjie Yang et autres

Infants and young children with laryngeal airway diseases should pay attention to the early symptoms and be diagnosed by electronic laryngoscopy as soon as possible. With good curative effect and few complications, low-temperature plasma surgery under visual laryngoscope is recommended. The formation …

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The design of infrared thermal imaging device for scoliosis examination

Zhuping Gu, Yang Zhan, Yuhan Sun, Qinchen Xu et autres

The design of this device puts infrared thermal imaging technology into scoliosis detection, in order to screen patients with scoliosis, reduce the incidence of scoliosis at the initial stage, take the rehabilitation training of scoliosis in early correction exercise and increase self-correction …

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CCDC 1917636: Experimental Crystal Structure Determination

Mengting Liu, Xueke Zhang, Ling Shen, Weiguang Sun et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2003660: Experimental Crystal Structure Determination

Mengting Liu, Lianghu Gu, Ling Shen, Xueke Zhang et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

[Analysis of 54 cases of thyroglossal duct cyst resection with hyoid bone preservation].

Pingfan Liu, Z. X. Ling, Zhongjie YANG, Ling Shen

Postoperative recurrence of thyroid hyoid cysts does not depend on whether the hyoid bone is removed, but on the residue of its branches.The significance of hyoid bone preservation is to narrow the scope of operation, reduce trauma and complications, and avoid the …

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