CareDx, Inc. (United States)

Elevated Donor‐Derived Cell‐Free DNA in Heart Transplants Beyond 5 Years: Early Warning or False Alarm?

Juka S. Kim, Erik J. Henricksen, James Pak, Yasbanoo Moayedi et autres

us, ca (code pays fourni par la source)

304.6: Longitudinal dd-cfDNA dynamics enable early detection of acute rejection in pediatric liver transplant recipients.

Agostina Arrigone, Guido Trezeguet Renatti, Daniela Fernández Souto, Débora Chan et autres

ar, us (code pays fourni par la source)

P4.737: Impact of tacrolimus trough intra-patient variability on donor-derived cell-free DNA and clinical outcomes.

David Taber, David Wojciechowski, Renata Ponsirenas, Peale Chuang et autres

us (code pays fourni par la source)

Donor‐Derived Cell‐Free DNA in Stable Pediatric Kidney Transplant Recipients: Influence of Donor Obesity and Recipient Size

Julia M. Steinke, Lyndsay A. Harshman, Kelly Kirshner, Arundhati Kale et autres

BACKGROUND: Donor-derived cell-free DNA (dd-cfDNA) is increasingly used as a noninvasive marker of kidney allograft injury, but adult-derived cutoffs may not be applicable to pediatric recipients, particularly in the setting of donor-recipient size mismatch. We evaluated dd-cfDNA levels in stable pediatric kidney …

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Molecular Classification Predicts Clinical Outcomes of Kidney Transplant Recipients With Microvascular Inflammation, Donor-specific Antibodies-negative and C4d-negative

Fahad Aziz, Hao Zhang, Peale Chuang, Wenlan Tian et autres

BACKGROUND: Microvascular inflammation (MVI), donor-specific antibodies (DSAs)-negative and C4d-negative, was recently defined as a distinct phenotype by Banff 2022 and has been associated with adverse clinical outcomes. We have developed a model for rejection-related molecular classification of renal allograft biopsies using gene …

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Serial Donor-derived Cell-free DNA Monitoring in a Kidney Transplant Recipient With Adenovirus Nephritis

Eric J. Xu, Samir Hirpara, Akil Serdar Kavcar, Natalia Jucha et autres

Opportunistic infection is one of the most common complications in solid organ transplantation. In particular, viral infections of the renal allograft pose a diagnostic and management dilemma because the histopathologic differences between viral allograft nephritis and acute rejection can be subtle yet …

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Expanded Allelic Diversity of Non‐Classical HLA Class I and MIC Loci Identified Using Full‐Gene Hybrid Capture‐Based Next‐Generation Sequencing

Itta Krishna Chaaithanya, Pawan Kumar Raghav, Nancy Y. Lee, Carla Wirtz et autres

Non-classical HLA Class I genes (HLA-E, -F, -G, -H) and MHC-related genes (MICA, MICB) regulate NK cell function and immune tolerance, yet their allelic diversity remains underexplored. Using capture-enriched full-gene sequencing of 943 healthy US transplant donors, we identified 26 novel alleles …

in, us (code pays fourni par la source)

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation

Jeffrey Alan Klein, David James Taber, David Wojciechowski, Didier A. Mandelbrot et autres

KEY POINTS: We assessed whether an initial donor-derived cell-free DNA elevation during routine surveillance was associated with allograft dysfunction and loss in kidney transplant recipients. Intermediate and high donor-derived cell-free DNA states were independently associated with 3.7-fold and 6.4-fold higher risks of …

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Demographics and Geographic Accessibility of Invasive Fungal Infection Clinical Trial Sites

Lucy X. Li, Jiashu Xue, Olivia S. Kates, Robin K. Avery et autres

This cross-sectional study investigates the geographic distribution and accessibility of clinical trials of systemic treatments for invasive fungal infections.

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Clinical Impact of dd-cfDNA Testing Frequency on Rejection Detection and Allograft Outcomes in the Kidney Outcomes AlloSure® Registry

Z. Zaky, E. Huang, A.J. Langone, P. Jain et autres

us (code pays fourni par la source)

Predicting the Continuous Spectrum of Kidney Transplant Rejection: Development and Validation of Blood Transcriptomics Markers

T. Vaulet, A. Pagliazzi, K. Wellekens, P. Koshy et autres

be, us (code pays fourni par la source)

Impact of HLA Mismatch on Baseline Donor-Derived Cell-Free DNA in Kidney Transplant Recipients

A. Conant, K. Mohib, K. Nashar, R. Daloul et autres

us (code pays fourni par la source)