Fuzhou General Hospital of Nanjing Military Command

pH-responsive bromophenol blue/NH2-mPEGylated BSA@MnO2 nanoplatform for rectal cancer marking after neoadjuvant therapy

qingrui Dong, Mengtao Li, Wanlin Chen, Pei Li et autres

After neoadjuvant therapy (NT), precise localization of original tumor margins remains challenging. Here, we developed a pH-responsive BPB/NH2-mPEG-BSA@MnO2 (BBNPBMs) nanoplatform. BSA coating, NH 2 -mPEG modification, and BPB loading generated a (198.7 ± 5.43) nm composite structure, enabling long-term local retention, tumor …

cn (code pays fourni par la source)

The effect and mechanism of TIPE in promoting M2 polarization through DcR3 in the microenvironment of colorectal cancer

Shiying Zhang, Chunlin Shen, Zeyang Lin, Qiang Zhu et autres

Elevated expression of tumor necrosis factor α-induced protein 8 (TIPE) is observed in colorectal cancer (CRC) and is known to regulate decoy receptor 3 (DcR3) expression while promoting M2 polarization of macrophages. However, the precise role of DcR3 in macrophage M2 polarization …

cn (code pays fourni par la source)

Overadjustment and Invalid Mediation Undermine IBD–Psoriasis Causal Inferences

Zhenzhen Xiao, Yunqian Zhuo, Rui Li, Yingjian Tan

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

cn, de (code pays fourni par la source)

[Otitis media with effusion in children: research advances from microecological mechanisms to precision diagnosis and treatment].

Pingfan Liu, Ling Shen, Zongtong Lin, Xinzhong Gao

Otitis media with effusion（OME） is a prevalent otologic condition in children that may lead to persistent hearing impairment and speech-language developmental delays. Recent studies have demonstrated that nasopharyngeal-middle ear microecological dysbiosis plays a central role in OME pathogenesis and chronicity. Advances in …

cn (code pays fourni par la source)

ALA-PDT Induces Ferroptosis in HPV-Infected Cells and Promotes M1 Macrophage Polarization

Bichun Xu, Youfan Zhang, Yixiu Zhong, Hui Liu et autres

Condyloma acuminatum (CA) is a recurrent human papillomavirus (HPV)-associated lesion characterized by a locally immunosuppressive microenvironment. Although 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has been used as a local treatment option for CA and other HPV-related lesions, the mechanisms underlying its immunomodulatory effects …

cn (code pays fourni par la source)

Integrated bioinformatics analysis reveals convergent molecular signatures associated with SERPINB7 and SERPINA12 deficiency

Zhenzhen Xiao, Yue Kang, Zixiao Zhao, Yue Zeng et autres

Background Pathogenic variants in SERPINA12 have recently been identified in patients with palmoplantar keratoderma (PPK). Clinically, SERPINA12-associated PPK shares substantial overlap with Nagashima-type palmoplantar keratoderma (NPPK) caused by SERPINB7 deficiency, although inflammatory manifestations appear to be more prominent in SERPINA12-associated disease. The …

cn, de, us (code pays fourni par la source)

Angiopoietin-like protein 2 promotes lower extremity arteriosclerosis obliterans progression via downregulating extracellular superoxide dismutase

Xiaobin Chen, Zuyou Fan, Jing Tu, Chen Lin

cn (code pays fourni par la source)

UV‐Triggered Barcode–CRISPR Cascade Biosensor for Amplification‐Free and Ultrasensitive Programmable microRNA Profiling in Lung Cancer

Jianqing Ye, Yongshi Shen, Jinyong Lin, Luyun Xu et autres

ABSTRACT Early screening and postoperative prognostic evaluation are essential for improving clinical outcomes in lung cancer. MicroRNAs (miRNAs) have emerged as promising minimally invasive biomarkers, and combined analysis of multiple miRNA markers can provide a comprehensive assessment of disease status. Here, we …

cn (code pays fourni par la source)

Parallel and chain mediating effects of physical activity and aging self-efficacy: community support and subjective well-being among Pre-K–9 teachers in Dongguan

Zhonghan Bao, Dezhuo Sun, Shirong Zhang, Shuqin Chen et autres

Abstract Objective To clarify the mediating role of aging self-efficacy and explore how physical activity and community support influence the subjective well-being of Pre-K–9 teachers in Dongguan, a manufacturing city. The aim is to provide empirical evidence in favor of improving the …

cn (code pays fourni par la source)

Teriflunomide Slows Osteoarthritis Progression via Wnt/β-Catenin and NLRP3 Pyroptosis Pathways.

Y D Zhang, Xiaojuan Zeng, Xiang Xu, Xiaojuan Zheng et autres

= 6 per group). TFM administration (30 mg/kg, every other day for 4 weeks) improved joint morphology, alleviated synovitis, and restored cartilage thickness and proteoglycan content relative to those observed in vehicle-treated animals. Collectively, these findings suggest that TFM exerts chondroprotective effects …

cn (code pays fourni par la source)

Reconsidering confounders in isotretinoin cumulative dose trials

Zhenzhen Xiao, Rui Li, Yingjian Tan

cn (code pays fourni par la source)

Correction: Molecular insights into nagashima-type palmoplantar keratoderma: SERPINB7 mutation spectrum and mechanistic perspectives

Zhenzhen Xiao, Yue Kang, Rui Li, Yingjian Tan

A correction refers to a change to their article that the author wishes to publish after publication. The publication of this article is subject to Frontiers' editorial approval.• Please read through all the templates before choosing • Pick the most relevant text …

cn, de (code pays fourni par la source)