Rong Li

Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics

Huan Ting Ong, Yuting Lou, Jake Turley, Ranmadusha M. Hengst et autres

Tissue mechanics influence diverse biological processes, yet directly linking stiffness measurements to spatially resolved molecular states in intact tissues remains challenging. Here we developed a paired-surface spatial mechanomics approach to map Young's modulus by nanoindentation on a fresh tissue surface and co-register …

sg, cn (code pays fourni par la source)

RXFP2 gene variation drives horn sexual differences and polledness in sheep

Buying Han, Dehui Liu, Xue Li, Cunxia Chen et autres

This study performed deep sequencing of the RXFP2 gene in three sheep breeds: PT, QHS, and HS. Association analysis identified four significant variant loci: SNP25, SNP57, SNP70, and SNP28. GMDR and LASSO analyses confirmed the crucial role of SNP28 in horn trait …

cn, in (code pays fourni par la source)

Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration

Yue Lu, Tezin A. Walji, Pratima Pandey, Chuanli Zhou et autres

Skeletal muscle regeneration is a multistep process involving the activation, proliferation, differentiation, and fusion of muscle stem cells, known as satellite cells. Fusion of satellite cell-derived myoblasts (SCMs) is indispensable for generating the multinucleated, contractile myofibers during muscle repair. However, the molecular …

us, sg (code pays fourni par la source)

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition

Albert Z. Liu, Akshay Narkar, K. W. Li, Thierry Bertomeu et autres

Abstract Aneuploidy is a hallmark of cancer and is a potential vulnerability that can be selectively targeted. To systematically identify genes that affect the incidence and fitness of aneuploid cells, we conducted a genome-wide CRISPR/Cas9 screen using NMS-P715, an inhibitor of the …

us, sg, th, ca (code pays fourni par la source)

The MADS-box transcription factor AaRLMA serves a crucial function in sustaining the integrity of cell wall, orchestrating secondary metabolites biosynthesis, and modulating pathogenicity in Alternaria alternata

Rong Li, Xiwang Wang, Pengfei Sun, Meiqi Gao et autres

cn (code pays fourni par la source)

Publisher Correction: Rejuvenation of aged oocyte through exposure to young follicular microenvironment

Haiyang Wang, Zhongwei Huang, Xingyu Shen, Yaelim Lee et autres

sg, us (code pays fourni par la source)

AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

Z. Li, Yihan Peng, Huai-Chin Chiang, Yanjun Gao et autres

R-loops are three-stranded DNA/RNA hybrids that are essential for various cellular pathways. However, when dysregulated, they lead to genomic instability and numerous human diseases. R-loops are tightly regulated, with RNase H1 acting as a key enzyme responsible for resolving DNA/RNA hybrids. Here, …

us (code pays fourni par la source)

3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation

Yang Yuan, Xiaoyan Wang, Xiaodi Yan, Nannan He et autres

cn (code pays fourni par la source)

Mechanosensitive Conjugated Oligoelectrolytes for Visualizing Temporal Changes in Live Cells

Ji‐Yu Zhu, Samuel J. W. Chan, Hongyue Cui, Alexander A. Mikhalovsky et autres

Membrane-intercalating conjugated oligoelectrolytes (COEs) are lipid-bilayer-spanning molecules that serve as fluorescent dyes for bioimaging. However, COE emission has thus far only been capable of visualizing dye location and their preferential accumulation in different membrane-bound intracellular compartments. Herein, we report the first example …

sg, us (code pays fourni par la source)

Exploring the potential role of soil protists in predicting banana health

Xiangyu Ren, Chen Liu, Yue Yang, Shuo Sun et autres

cn (code pays fourni par la source)

Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma

Bo Sun, Rong Li, Ning Ji, Han Liu et autres

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic …

cn (code pays fourni par la source)

Association Between Serum Levels of Sestrin-2 and Galectin-3 and Atrial Remodelling in Patients with Atrial Fibrillation

Rong Li, Yanlin L. Gao, Wei Cheng, Sheng Zhao

OBJECTIVE: To explore the prognostic significance of Sestrin-2 and Galectin-3 levels in atrial fibrillation complicated by left atrial remodelling, aiming to offer novel insights for prevention, treatment, and follow-up strategies. STUDY DESIGN: Analytical study. Place and Duration of the Study: Department of …

cn (code pays fourni par la source)