Ning Ji

Study on the hole and knob related impurities in the purification of bispecific antibodies

H Y Chen, Ning Ji

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2

Hao Cheng, Fang Nan, Ning Ji, Xiao Ma et autres

CD4+Foxp3+ regulatory T cells are essential for maintaining immune tolerance and preventing excessive inflammation, making them promising candidates for treating autoimmunity and GvHD. However, the translation of regulatory T cell therapy into clinical practice poses substantial challenges. Here, we show that adoptive …

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[Dynamic Succession of Urokinase-Type Plasminogen Activator in an Oral Squamous Cell Carcinoma Model].

Yuwen Luo, Xuelin Huang, Bomiao Cui, Ning Ji et autres

Objective: To systematically characterizes the temporal changes in urokinase-type plasminogen activator (uPA) over the course of neoplastic progression using a mouse oral squamous cell carcinoma (OSCC) model induced by 4-nitroquinoline-1-oxide (4-NQO). Methods: = 15), which received sterile water. At 12, 16, 20, …

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Impact of microwave treatment in conjunction with modified atmosphere packaging on postharvest fungal diseases in fresh Gastrodia elata

Xu Zhang, Nanxin Zhang, Mingjin Li, Wencong Zhang et autres

Diseases caused by tuber fungi severely disrupt the storage life and quality of post-harvest Gastrodia elata ( G. elata ). Herein, it was found that the decay of G. elata tubers is primarily attributed to Fusarium solani and Penicillium crustosum . To …

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Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia

Zhongyu Liu, Lu Xing, Wenlong Huang, Ning Ji et autres

Fibrous dysplasia is a skeletal disorder caused by activating mutations in Gαs, leading to bone fractures, deformities, and pain. Protein kinase A (PKA), the principal effector of Gαs, plays critical roles in various biological processes. However, its role in fibrous dysplasia is …

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Targeting the IL-6–Th17–Neutrophil Axis Reduces Local Inflammation in Stomatitis

Yang Wang, Dan Zhang, Yifei Lin, Xianming Fan et autres

Recurrent aphthous stomatitis (RAS) is a common chronic oral disease with unclear pathogenesis. Chronic inflammation associated with RAS has been linked to the dysregulation of local immune responses. We used a murine model of acetic acid–induced chemical stomatitis (CS) to assess changes …

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Corrigendum to “Cysteine dioxygenase type 1 promotes adipogenesis via interaction with peroxisome proliferator-activated receptor gamma” [Biochem. Biophys. Res. Commun. 458 (1) (2015), 33311]

Peng Deng, Yi Chen, Ning Ji, Yunfeng Lin et autres

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Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells

Tingyu Chen, Yiming Xu, Fan Yang, Ning Ji et autres

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Association between glucose time-in-range and the severity of metabolic dysfunction-associated steatotic liver disease in Chinese adults with type 2 diabetes mellitus

Chunhua Wang, Xiaoyun Ji, Ning Ji, Qingfeng Yan et autres

BACKGROUND: This study investigated the correlation between glucose time-in-range (TIR) and hepatic steatosis severity or liver fibrosis risk in Chinese adults with type 2 diabetes mellitus (T2DM) comorbid with metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: Participants with T2DM were evaluated for …

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Brain-targeting drug delivery systems: The state of the art in treatment of glioblastoma

Bo Sun, Rong Li, Ning Ji, Han Liu et autres

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and a poor prognosis. The blood-brain barrier (BBB) and the blood-tumor barrier (BTB) present significant obstacles to the efficacy of tumor-targeted pharmacotherapy, thereby impeding the therapeutic …

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Knockdown of CCNB1 alleviates high glucose-triggered trophoblast dysfunction during gestational diabetes via Wnt/β-catenin signaling pathway

Biru Xiao, Wenmiao Zhang, Ning Ji, Qiuyue Chen

Abstract Gestational diabetes mellitus (GDM), defined as glucose intolerance occurring or first detected during pregnancy, affects approximately 8% of pregnancies worldwide. The dysfunction of trophoblasts in pregnancies complicated by GDM is associated with changes in trophoblast cell functions, resulting in compromised proliferation …

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Protein Kinase A is a Dependent Factor and Therapeutic Target in Fibrous Dysplasia

Xuefeng Zhao, Zhongyu Liu, Lu Xing, Wenlong Huang et autres

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