Rozalyn M. Anderson

A National Institute on Aging workshop on sex differences in health across the lifespan

Jeffrey Pea, Siobhan Addie, Fabrisia Ambrosio, Rozalyn M. Anderson et autres

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Multimorbidity as a predictor of mortality in companion dogs

Eric R. Foreman, Laura Corlin, Kate E. Creevy, Jessica M. Hoffman et autres

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Gut bacterial metabolite imidazole propionate potentiates Alzheimer’s disease pathology

Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R. McGregor et autres

Abstract The gut microbiome modulates metabolic and neurovascular processes implicated in Alzheimer’s disease and related dementias (ADRD), but the underlying mechanisms remain unclear. Here, we identify the bacterial metabolite imidazole propionate (ImP) as a modifier of ADRD pathology. In a cohort of …

Mapping the canine gut microbiome: insights from the Dog Aging Project

Tal Bamberger, Efrat Muller, Yadid M. Algavi, Ashlee Greenier et autres

Companion dogs (Canis lupus familiaris) offer a unique model for studying the gut microbiome and its relation to aging due to their cohabitation with humans, sharing similar environments, diets, and healthcare practices. Here, we present the Dog Aging Project (DAP) Precision cohort, …

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Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia

Hadi Esfandi, Mahshad Javidan, Eric R. McGregor, Rozalyn M. Anderson et autres

Cerebral hemodynamics is tightly regulated by arteriolar vasodynamics. In this study, a systems biology approach was employed to investigate how the interplay between passive, myogenic, neurogenic, and astrocytic responses shapes arteriolar vasodynamics in small rodents. A model of neurovascular coupling is proposed …

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eLife Assessment: Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle

Rozalyn M. Anderson

Intermittent fasting (IF) has emerged as a powerful dietary intervention with profound metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed comprehensive proteomics and transcriptomics analysis to investigate the systemic and organ-specific adaptations …

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Dietary restriction in aging and longevity

Tomas Schmauck‐Medina, Sofie Lautrup, Andrea Di Francesco, Sarah Jayne Mitchell et autres

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Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons

Eric R. McGregor, Katie J. Osterbauer, Grace E. Gustafson, Josef P. Clark et autres

Adiponectin is an adipose tissue-derived peptide hormone that exerts beneficial metabolic effects in many tissues throughout the body. It is most well-known for its ability to enhance insulin sensitivity and dampen chronic inflammation. The impact of age on adiponectin is controversial; levels …

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The Sixth Annual Symposium of the Midwest Aging Consortium

Ines Sturmlechner, Sarah Ashiqueali, Hélène Martini, Karla Valdivieso et autres

Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its inception in 2019, the Midwest Aging Consortium (MAC) has provided an engaging platform for aging …

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How and why does aging occur? Updating evolutionary theory to meet a new era of data

C Jessica E Metcalf, Rozalyn M. Anderson, Michael Hochberg, Joanna Masel et autres

Our ability to define the causes of aging could enable targeted interventions to extend healthspan. Classical evolutionary models based on individual age have provided critical insights into empirical trajectories of aging; however, gaps remain. We argue that technological advances in data capture, …

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Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys

Salma I Abou Elhassan, Josef P. Clark, Di Kuang, Timothy W. Rhoads et autres

Caloric restriction (CR) without malnutrition delays aging in diverse species, including primates, with metabolic changes implicated in this process. To facilitate exploration of CR metabolism with aging, we developed a 15-minute LC-MS/MS metabolomics and lipidomics method, leveraging monophasic extractions and wide elution-strength …

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Aging Reprogrammed: Nutrition, Metabolism, and Health

Rozalyn M. Anderson

Rozalyn Anderson; Aging Reprogrammed: Nutrition, Metabolism, and Health, Innovation in Aging, Volume 9, Issue Supplement_2, 1 December 2025, igaf122.1388,