Sarah Ashiqueali

Impact of miR-181a-5p and miR-1249-3p treatment on the visceral adipose tissue transcriptome of female mice

Driele Neske Garcia, Bianka M. Zanini, Sarah Ashiqueali, Miguel A Brieño-Enriquez et autres

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The Sixth Annual Symposium of the Midwest Aging Consortium

Ines Sturmlechner, Sarah Ashiqueali, Hélène Martini, Karla Valdivieso et autres

Geroscience research benefits from interdisciplinary approaches, team science, and collaborations, which collectively facilitate the discovery of aging mechanisms and their translation into tangible, clinical interventions. Since its inception in 2019, the Midwest Aging Consortium (MAC) has provided an engaging platform for aging …

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The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy

Md Tanjim Alam, Mishfak A. M. Mansoor, Sarah Ashiqueali, Paweł Golusiński et autres

Cellular senescence is defined as a state of permanent cell cycle arrest, providing a natural barrier against cancer. However, senescent cells are very metabolically active and secrete a complex mixture of bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP), which …

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ESPO and Biological Sciences Section Symposium: Exploring New Horizons in Geroscience

Nisi Jiang, Sarah Ashiqueali

Abstract Over the past year, the field of gerontology has made significant strides, deepening our understanding of the biological mechanisms underlying aging and paving the way for potential interventions. Breakthroughs in cellular and molecular research have provided new insights into the fundamental …

Extracellular vesicles from cyclic mice modulate liver transcriptome in estroupause mice independent of age

Bianka M. Zanini, Bianca M. Ávila, Jéssica D. Hense, Driele Neske Garcia et autres

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Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida

Blanka Rogina, Rozalyn M. Anderson, Nathan K. LeBrasseur, Sean Curan et autres

The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic and nongenetic interventions have been described, which successfully extend healthspan and lifespan …

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Fecal microbiota transplant from long-living Ames dwarf mice alters the microbial composition and biomarkers of liver health in normal mice

Sarah Ashiqueali, Natalie Hayslip, Diptaraj S. Chaudhari, Augusto Schneider et autres

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Circulating microRNAs as a Prognostic Tool to Determine Treatment Efficacy in Lung Cancer Patients Undergoing Pembrolizumab PD-1 Blockade Immunotherapy

Mishfak A. M. Mansoor, Xiang Zhu, Sarah Ashiqueali, Md Tanjim Alam et autres

Background: Pembrolizumab has recently emerged as a PD-1 blockade immunotherapy treatment for lung cancer. It is critical that such treatment strategies for lung cancer should be chosen not only on the basis of histopathological features and the expression of targetable cell surface …

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FECAL TRANSPLANT FROM LONG LIVING AMES DWARF MICE ALTERS THE MICROBIOME AND BIOMARKERS OF LIVER HEALTH IN CONTROL MICE

Sarah Ashiqueali, Natalie Hayslip, Diptaraj S. Chaudhari, Augusto Schneider et autres

Abstract Aging is associated with intestinal dysbiosis, a condition characterized by diminished microbial biodiversity and inflammation. This leads to increased vulnerability to extraintestinal manifestations such as autoimmune, metabolic, and neurodegenerative conditions and accelerates mortality. As such, modulation of the gut microbiome is …

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ACTIVE IMMUNIZATION AGAINST MYOSTATIN AND ACTIVIN A IMPROVES SKELETAL MUSCLE STRENGTH DESPITE GH/IGF-1 DEFICIENCY

Mishfak A. M. Mansoor, Sarah Ashiqueali, Md Tanjim Alam, A Francie Lasseter et autres

Abstract Muscle wasting is a significant hurdle in patients due to immobilization, prolonged bed rest, and injury. In particular, the older population develops sarcopenia, characterized by progressive loss of muscle strength due to natural aging. However, there are no FDA-approved drugs for …

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EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE

Bianka M. Zanini, Bianca M. Ávila, Jéssica D. Hense, Driele Neske Garcia et autres

Abstract Background Exosomes are extracellular vesicles secreted by cells that contain microRNAs (miRNAs). These miRNAs can induce changes in gene expression and function of recipient cells. In different cells exosome content can change with age and physiological state affecting tissues function and …

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Gene and transcript expression patterns, coupled with isoform switching and long non-coding RNA dynamics in adipose tissue, underlie the longevity of Ames dwarf mice

Sebastian Cano-Besquet, Maiyon Park, Nadia Berkley, Michelle Wong et autres

Our study investigates gene expression in adipose tissue of Ames dwarf (df/df) mice, whose deficiency in growth hormone is linked to health and extended lifespan. Recognizing adipose tissue influence on metabolism, aging, and related diseases, we aim to understand its contribution to …

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