Jea Woo Kang

Gut bacterial metabolite imidazole propionate potentiates Alzheimer’s disease pathology

Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Kaj Blennow et autres

The gut microbiome modulates metabolic and neurovascular processes implicated in Alzheimer's disease and related dementias (ADRD), but the underlying mechanisms remain unclear. Here, we identify the bacterial metabolite imidazole propionate (ImP) as a modifier of ADRD pathology. In a cohort of 1196 …

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Gut bacterial metabolite imidazole propionate potentiates Alzheimer’s disease pathology

Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R. McGregor et autres

Abstract The gut microbiome modulates metabolic and neurovascular processes implicated in Alzheimer’s disease and related dementias (ADRD), but the underlying mechanisms remain unclear. Here, we identify the bacterial metabolite imidazole propionate (ImP) as a modifier of ADRD pathology. In a cohort of …

Fecal levels of short‐chain fatty acids and prominent bacterial taxa involved in their production are inversely associated with amyloid‐positive status

Jessamine F. Kuehn, Qijun Zhang, Margo B. Heston, Jea Woo Kang et autres

BACKGROUND: Short-chain fatty acids (SCFA), including acetate, propionate, and butyrate, are abundant gut bacterial metabolites produced via the fermentation of dietary fibers and resistant starch. Several lines of evidence, particularly in preclinical mouse models, suggest a protective role of SCFA against Alzheimer's …

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Plasma Levels of the Gut Bacteria‐Derived Metabolite Imidazole Propionate Are Negatively Associated with Cognitive Scores

Jea Woo Kang, Vaibhav Vemuganti, Erin McMullen Jonaitis, Sterling C Johnson et autres

BACKGROUND: Among the various modifiable risk factors for AD development, the gut microbiome stands out as a potential therapeutic target, offering opportunities for intervention in the very early stages to potentially prevent disease onset. Notably, specific gut microbial metabolites may critically modulate …

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Fecal short‐chain fatty acids vary by sex and amyloid status

Jessamine F. Kuehn, Qijun Zhang, Margo B. Heston, Jea Woo Kang et autres

Abstract INTRODUCTION Short‐chain fatty acids (SCFAs), produced by gut microbes, influence Alzheimer's disease (AD) pathology in animals. Less is known about SCFAs and AD in humans. We profiled feces of adults along the AD continuum to investigate gut microbiome and SCFA associations …

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Fecal Short-Chain Fatty Acids Vary by Sex and Amyloid Status

Jessamine F. Kuehn, Qijun Zhang, Margo B. Heston, Jea Woo Kang et autres

INTRODUCTION: Short-chain fatty acids (SCFAs), produced by gut microbes, influence Alzheimer's disease (AD) pathology in animals. Less is known about SCFAs and AD in humans. We profiled feces of adults along the AD continuum to investigate gut microbiome and SCFA associations with …

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Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Federico E. Rey, Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang et autres

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Gut microbiome compositional and functional features associate with Alzheimer's disease pathology

Jea Woo Kang, Lora A. Khatib, Margo B. Heston, Amanda Hazel Dilmore et autres

BACKGROUND: The gut microbiome is a potentially modifiable risk factor for Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited. METHODS: Shallow-shotgun metagenomics was used to analyze the fecal microbiome of participants in the Wisconsin Microbiome …

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A low-dose prebiotic fiber supplement reduces lipopolysaccharide-binding protein concentrations in a subgroup of young, healthy adults consuming low-fiber diets

Eduardo Z. Romo, Brian V. Hong, Joanne K. Agus, Jea Woo Kang et autres

Although the beneficial effects of fiber supplementation on overall health and the gut microbiome are well-known, it is not clear whether fiber supplementation can also alter the concentrations of lipopolysaccharide-binding protein (LBP), a marker of intestinal permeability. A secondary analysis of a …

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Relationships Between Microbiome‐derived Short Chain Fatty Acids and Alzheimer’s Disease Pathology Biomarkers: A Human Cohort Study

Jessamine F. Kuehn, Margo B. Heston, Matthew F Warren, Jea Woo Kang et autres

Abstract Background Alzheimer’s Disease (AD) is the most common form of dementia, and therapies that effectively halt disease progression are lacking. Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are abundant gut bacterial metabolites produced via fermentation of dietary fibers …

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Gut microbiome features co‐occur in different groups of Alzheimer’s disease phenotypes and genotypes

Jea Woo Kang, Lora A. Khatib, Amanda Hazel Dilmore, Margo B. Heston et autres

Abstract Background Gut microbiome features are known to be different in Alzheimer’s disease (AD) patients compared with cognitively normal. Evidence suggests that the gut microbiota may be related to the pathology of AD. We examined the association between the gut microbiome and …

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Gut microbiome features associate with cognitive scores in individuals at risk for Alzheimer’s disease

Jea Woo Kang, Lora A. Khatib, Amanda Hazel Dilmore, Margo B. Heston et autres

Abstract Background Gut microbiome features have been linked with many diseases including Alzheimer’s disease (AD). Evidence suggests that the gut microbiota may impact cognition of AD patients. We explored the association of gut microbiota and three PACC3 cognitive scores in individuals at …

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