Yadid M. Algavi

Mapping the canine gut microbiome: insights from the Dog Aging Project

Tal Bamberger, Efrat Muller, Yadid M. Algavi, Ashlee Greenier et autres

Companion dogs (Canis lupus familiaris) offer a unique model for studying the gut microbiome and its relation to aging due to their cohabitation with humans, sharing similar environments, diets, and healthcare practices. Here, we present the Dog Aging Project (DAP) Precision cohort, …

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Fecal metabolic signals are associated with changes in microbiota and systemic metabolic pathways in Crohn’s disease

Nina Levhar, Rotem Hadar, Tzipi Braun, Hila Shacham et autres

Metabolites play a crucial role in the interactions between the host and its microbiome, influencing disease pathogenesis. To explore metabolic signals linked to Crohn’s Disease (CD), we analyzed paired fecal and serum metabolomics, combined with microbial characterization. Metabolites were identified using liquid …

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TAGINE: fast taxonomy-based feature engineering for microbiome analysis

Shiri Baum, Ido Meshulam, Yadid M. Algavi, Omri Peleg et autres

Summary: TAGINE is a feature engineering algorithm that leverages the microbial taxonomic tree to optimize feature sets in microbiome data for predictive modeling. The algorithm starts with features at high taxonomic levels and iteratively splits them into lower-level clades in cases where …

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TAGINE: Fast Taxonomy-based Feature Engineering for Microbiome Analysis

Scott T. Baum, Ido Meshulam, Yadid M. Algavi, Omri Peleg et autres

Abstract Summary TAGINE is a feature engineering algorithm that leverages the microbial taxonomic tree to optimize feature sets in microbiome data for predictive modeling. The algorithm starts with features at high taxonomic levels and iteratively splits them into lower-level clades in cases …

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Protein Catabolites as Blood‐Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project

Benjamin R. Harrison, Maria Partida‐Aguilar, Abbey Marye, Danijel Djukovic et autres

Our understanding of aging has grown through the study of systems biology, including single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and environmental variation in nature. …

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Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience

Jena N. Prescott, Amber J. Keyser, Paul Litwin, Matthew D. Dunbar et autres

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Mapping the canine microbiome: Insights from the Dog Aging Project

Tal Bamberger, Efrat Muller, Yadid M. Algavi, Ashlee Greenier et autres

Abstract Companion dogs ( Canis lupus familiaris ) offer a unique model for studying the gut microbiome and its relation to aging due to their cohabitation with humans, sharing similar environments, diets, and healthcare practices. Here, we present the Dog Aging Project …

il, us (code pays fourni par la source)

Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project

Benjamin R. Harrison, Maria Partida‐Aguilar, Abbey Marye, Danijel Djukovic et autres

Our understanding of age-related physiology and metabolism has grown through the study of systems biology, including transcriptomics, single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and …

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DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project

Blaise L. Mariner, Brianah M. McCoy, Ashlee Greenier, Layla Brassington et autres

Within a species, larger individuals often have shorter lives and higher rates of age-related disease. Despite this well-known link, we still know little about underlying age-related epigenetic differences, which could help us better understand inter-individual variation in aging and the etiology, onset, …

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Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging

Brianah M. McCoy, Blaise L. Mariner, Claire F. Cheng, Elizabeth Slikas et autres

Dogs exhibit striking within-species variability in lifespan, with smaller breeds often living more than twice as long as larger breeds. This longevity discrepancy also extends to health and aging-larger dogs show higher rates of age-related diseases. Despite this well-established phenomenon, we still …

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Relative dispersion ratios following fecal microbiota transplant elucidate principles governing microbial migration dynamics

Yadid M. Algavi, Elhanan Borenstein

Microorganisms frequently migrate from one ecosystem to another. Yet, despite the potential importance of this process in modulating the environment and the microbial ecosystem, our understanding of the fundamental forces that govern microbial dispersion is still lacking. Moreover, while theoretical models and …

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Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar et autres

Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n = 380) has considered diet-omics domains simultaneously to detect complex interactions …

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