Accès ouvert
2026
preprint
OpenAlex
Eric R. McGregor, Cassandra Joan McGill, Nicholas L. Arp, Josef P. Clark et autres
The metabolite acetyl-CoA plays a central role in cellular metabolic homeostasis. As part of the secretory pathway, acetyl-CoA is imported into the endoplasmic reticulum (ER) by a membrane-bound transporter AT-1 (SLC33A1). AT-1 has been linked to peripheral neuropathy (heterozygous mutations), developmental delay …
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Accès ouvert
2025
article
OpenAlex
Salma I Abou Elhassan, Josef P. Clark, Di Kuang, Timothy W. Rhoads et autres
Caloric restriction (CR) without malnutrition delays aging in diverse species, including primates, with metabolic changes implicated in this process. To facilitate exploration of CR metabolism with aging, we developed a 15-minute LC-MS/MS metabolomics and lipidomics method, leveraging monophasic extractions and wide elution-strength …
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Accès ouvert
2022
article
OpenAlex
Qi Yi, Di Kuang, Kylan Kelley, William Buchser et autres
The dual specificity phosphatase (DUSP) family has catalytically inactive members, called pseudophosphatases. They have mutations in their catalytic motifs that render them enzymatically inactive. This study analyzes the significance of two pseudophosphatases, MK-STYX [MAPK (mitogen-activated protein kinase phosphoserine/threonine/tyrosine-binding protein]) and STYX (serine/threonine/tyrosine-interacting …
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2021
article
OpenAlex
Qi Yi, Di Kuang, Kylan Kelley, William Buchser et autres
MK‐STYX [MAPK (mitogen‐activated protein kinase) phosphoserine/threonine/tyrosine‐binding protein] is an atypical member of the dual‐specificity family subfamily of protein tyrosine phosphatases. It is catalytically inactive due to mutations at critical histidine and cysteine residues within its signature active motif (HCX5R). Therefore, MK‐STYX is …
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