Wei Dai

Cross-population heterogeneity in the association between estimated sdLDL-C and gallstone disease: a dual-source two-sample cross-sectional study

Wei Dai, Weihao Guo, Hang Shen, Qikai Sun et autres

Background While conventional lipid parameters are linked to gallstone disease, the specific role of small dense low-density lipoprotein cholesterol (sdLDL-C)—a highly atherogenic subfraction—remains unexplored. We aimed to evaluate the independent association between estimated sdLDL-C and gallstone risk, and to map potential cross-population …

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Quantum Demodulation of QAM Signals at a Rydberg atomic Homodyne Receiver

Zhongxiang Li, Dezhi Zheng, Chun Hu, Wei Dai et autres

Facing the trend of 5G/6G communications toward high spectral efficiency and low power consumption, RF receivers urgently need to overcome the triple challenges of high sensitivity, terahertz (THz) coverage, and system integration. Conventional approaches are limited by electronic thermal noise, band correlation …

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Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells

Shenglan Liu, Junhong Wu, Hao Huang, Bin Hu et autres

BACKGROUND: Colorectal cancer (CRC) is a prevalent malignant tumor globally, ranking third in incidence and second in mortality. Metastasis is the main cause of death in patients with CRC. Solanum nigrum L. (SNL), a traditional Chinese medicinal herb endowed with detoxification, blood …

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RAR-Based Prognostic Model for Predicting Overall Survival in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Multicenter Study

Maoqing Tan, Yifan Liu, Wei Dai, Yanling Chen et autres

Purpose: Hepatitis B virus-related hepatocellular carcinoma poses a significant global health challenge. This study aimed to develop and validate a novel prognostic nomogram integrating the red blood cell distribution width-to-albumin ratio for predicting patients' overall survival. Patients and Methods: A retrospective cohort …

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865-P: Efficacy and Safety of a Novel Oral Small Molecule GLP-1RA in Chinese Obese Adults without Diabetes

Weijun Gu, Lihui Zhang, Ling Li, Wei Dong et autres

Introduction and Objective: HRS-7535, a novel small molecule GLP-1RA, demonstrated promising weight loss (WL) in a phase 1 trial. This phase 2 study evaluated its efficacy and safety in obese adults without diabetes. Methods: In this randomized, double-blind, placebo (PBO)-controlled, multicenter study, …

Comparison of efficacy and safety of lenvatinib vs. apatinib in combination with hepatic arterial infusion chemotherapy and immune checkpoint inhibitors for unresectable intrahepatic cholangiocarcinoma: A multicenter retrospective study.

Li Xu, Xinhao Xiong, Jian‐Hong Zhong, Rongce Zhao et autres

e16256 Background: For unresectable intrahepatic cholangiocarcinoma (uICC), combining targeted drugs with chemotherapy (systemic or hepatic arterial infusion chemotherapy, HAIC) and immune checkpoint inhibitors (ICIs) has become a common treatment. However, evidence-based medical evidence to choose between different targeted drugs and ICIs is …

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Conversion therapy for initially unresectable intrahepatic cholangiocarcinoma: A multicenter real-world study.

Xinhao Xiong, Wei Dai, Jinzhang Chen, Jian‐Hong Zhong et autres

4118 Background: Currently, studies on conversion therapy for intrahepatic cholangiocarcinoma (ICC) are relatively limited. Effectiveness and optimization strategies of conversion therapy in real world remain unclear. This study aims to analyze the efficacy of locoregional combined with systematic therapy in patients with …

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The ‘side effects’ of digitalization: A study on role overload and job burnout of employees

Quanjun Zhang, Wei Dai, Jian Chen, Yuan Gu

In the context of the digital economy, enterprise digitalization represents a significant opportunity to enhance core competitiveness. Nevertheless, the digitalization of enterprises may have unanticipated effects on employee's mental health, which could impede the digital advancement of the enterprise. Such consequences may …

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Association between the advanced lung cancer inflammation index and all-cause mortality in the US MASLD/MetALD patient population: a cohort study

Hang Li, Gaohui Chen, Shiting Bao, Guotai Lin et autres

BACKGROUND: The relationship between the Advanced Lung Cancer Inflammation Index (ALI) and all-cause mortality in patients with Metabolic Dysfunction-Associated Steatohepatitis and Metabolic-Associated Alcoholic Liver Disease and other combination etiology of steatosis (MASLD/MetALD & Mixed Etiology Steatosis) is not well-understood. Current evidence is …

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In Vitro and In Vivo Inhibition of Pseudorabies Virus Replication by Natural Plant Aconitum tanguticum and Belamcanda chinensis

Zhaohua Wang, Wei Dai, Xiaohuan Yan, Zhi Yi Su et autres

It has been widely known that the Pseudorabies virus (PRV) presents a significant health risk to swine, inflicting considerable economic losses in breeding industry, but those basic function about this disease still keeps unknown. For further understanding its potentiality, the antiviral potential …

Rydberg communication antennas with self-decoupling for dynamic radar interference based on heterodyne technology

Ge Gao, Minze Chen, Haonan Feng, Aobei Chen et autres

The Rydberg atomic communication antenna exhibits exceptional properties superior to traditional antennas. The use of heterodyne technology further establishes a foundation for high-precision digital communication. However, current signal solvers limit its application in integrated radar-communication systems. To address this, we propose a …

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[Analysis of PIKFYVE gene expression, clinical significance, and experimental validation based on TCGA database in hepatocellular carcinoma].

Li Ming Wen, Yuan Guo, David X. Zheng, Qiang Hou et autres

PIKFYVE, as an independent risk factor, is expected to be developed into a biomarker for clinical diagnosis, offering a reference for novel therapeutic agents in HCC.

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