Yuan Lin Guo

CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway

Linxi Li, Anju Zuo, Ruoyu Yin, Qiangqiang Liu et autres

Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA) has been …

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Compression and Rendering of Time-varying Interplanetary Volumes

Lili Bao, Yanxia CAI, Rui Wang, Yuan Lin Guo et autres

We propose a compression and rendering method for time-varying interplanetary volumes, by reducing the redundancy in solar wind based on the coronal hole characteristics, slow change and rotation along with the sun. We regard the firsttime step as the solar wind background …

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Prognostic and predictive value of tumor infiltration proportion within lymph nodes in N1 colorectal cancer

Rujie Chen, Jun Wei Zhu, Dong Xu, Xiaoyan Fan et autres

Introduction: Lymph node metastasis is a crucial determinant of prognosis in colorectal cancer (CRC), significantly impacting survival outcomes and treatment decision-making. This study aims to evaluate the prognostic value of tumor infiltration proportion within lymph nodes (TIPLN) in N1 CRC patients and …

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[Analysis of PIKFYVE gene expression, clinical significance, and experimental validation based on TCGA database in hepatocellular carcinoma].

Li Ming Wen, Yuan Lin Guo, David X. Zheng, Qiang Hou et autres

PIKFYVE, as an independent risk factor, is expected to be developed into a biomarker for clinical diagnosis, offering a reference for novel therapeutic agents in HCC.

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[Study of the occurrence of metabolic dysfunction-associated fatty liver disease in obstructive sleep apnea hypopnea syndrome and its risk factors].

Yuan Lin Guo, D Y Zhang, Shunjiang Xu, M J Zhang et autres

OSAHS is strongly associated with MAFLD,and the involvement of OSAHS in the occurrence and development of MAFLD may be related to obesity,lipid metabolism disorders,insulin resistance,inflammatory responses,and intermittent hypoxia.

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Molecular Engineering Development of β-Galactosidase-Activatable Fluorogenic Probes for Precise Senescence Tracking in Cells, Tissues and a Mouse Model of Psoriasis

Xing Lv, Ying Yu, Zhuowei Chen, Guangwei Wang et autres

Long-term administration of atorvastatin had no effect on the occurrence and progression of spontaneous hypertensive intracerebral hemorrhage in mice

Xiaoming Bian, Yuan Lin Guo, Jingyu Chen, Wu Song et autres

Abstract Background Intracerebral hemorrhage (ICH) is a catastrophic disease with limited treatment options. Statins and low low-density lipoprotein cholesterol (LDL-C) levels have been reported to be associated with increased risk of ICH. Safety concerns of statins were raised as statins become the …

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Age Difference in the Connection Between Systemic Inflammatory Response and Metabolic Syndrome

Haishan Wei, Dan Xu, Jiying Chen, Haiyan Yu et autres

BACKGROUND: This research aims to investigate the connection between systemic inflammatory response and metabolic syndrome (MetS) across different age groups, with the aim of proposing more targeted recommendations. METHODS: This study enrolled 15 959 adults from the 2001-2018 National Health and Nutrition …

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CRISPR-Cas9 mediated AGO2 knockout inhibits tumorigenesis in human colorectal cancer cells

Yizhi Zhu, Gengfang Wang, Haoran Xu, Yuan Lin Guo

AGO2 plays a vital role in small RNA-guided gene silencing, which has been implied in the tumorigenesis of different types of tumors. Fundamentally, increased expression of AGO2 protein is associated with cancer progression and metastasis. This study aims to investigate the molecular …

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CTRP9 alleviates diet induced obesity through increasing lipolysis mediated by enhancing autophagy-initiation complex formation.

Shengyun Lei, Xuehui Li, Anju Zuo, Shiyan Ruan et autres

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Non-invasive assessment of periodontal inflammation by continuum-removal hemodynamic spectral indices

Yuan Lin Guo, Yixiang Huang, Changping Huang, Xuejian Sun et autres

Abstract Background Hyperspectral techniques have aroused great interest in non-invasively measuring periodontal tissue hemodynamics. However, current studies mainly focused on three typical inflammation stages (healthy, gingivitis and periodontitis) and practical approaches for using optical spectroscopy for early and precisely detection of periodontal …

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Amplified Ferroptosis and Apoptosis Facilitated by Differentiation Therapy Efficiently Suppress the Progression of Osteosarcoma

Chao He, Yuhang Jiang, Yuan Lin Guo, Zenghui Wu

Osteosarcoma (OS) is the most frequent osseous neoplasm among young people aged 10-20. Currently, the leading treatment for osteosarcoma is a combination of surgery and chemotherapy. However, the mortality remains high due to chemoresistance, metastasis, and recurrence, attributing to the existence of …

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