Bin Hu

Direct Ser797 Interacted Pteridine-7(8 H )-one Derivatives as Highly Selective and Orally Available EGFRL858R/T790M/C797S Inhibitors

Wenzhe Jiang, Yongning He, Yongxiang Wang, Hongguang Du et autres

Abstract The EGFRC797S mutation is the main mechanism of acquired resistance to Osimertinib in NSCLC. There is an urgent need for small-molecule inhibitors to overcome Osimertinib-resistance. In this article, we developed a series of pteridin-7(8H)-one-derived inhibitors of EGFRL858R/T790M/C797S (EGFRLR/TM/CS) integrating direct interactions …

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Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells

Shenglan Liu, Junhong Wu, Hao Huang, Bin Hu et autres

BACKGROUND: Colorectal cancer (CRC) is a prevalent malignant tumor globally, ranking third in incidence and second in mortality. Metastasis is the main cause of death in patients with CRC. Solanum nigrum L. (SNL), a traditional Chinese medicinal herb endowed with detoxification, blood …

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Seven Novel and Three Known Mutations in FOXL2 in 10 Chinese Families with Blepharophimosis Syndrome

Binshan Lin, Binghui Zeng, Jing Zhao, Tingting Xu et autres

BACKGROUND: Blepharophimosis syndrome (BPES) is characterized by eyelid malformation with occasional premature ovarian failure. Mutations in FOXL2 underlie a fraction of BPES cases. OBJECTIVE: We aimed to investigate the genetic basis of BPES in 26 Chinese families that included 78 patients. METHODS: …

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Efficacy of 694-nm fractional Q-switched ruby laser (QSRL) combined with sonophoresis on levorotatory vitamin C for treatment of melasma in Chinese patients

Haiyuan Zhou, Bin Hu, C. Zhang

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Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in Chinese cancer patients

Y.-F. He, Wei Wei, Xiaoge Zhang, Yixuan Li et autres

BACKGROUND AND OBJECTIVE: 5-fluorouracil (5-FU) is still a widely used anticancer drug. More than 85% of the 5-FU administered is catabolized by dihydropyrimidine dehydrogenase (DPD) in the liver. However, mutations in the DPD gene have been found to be associated with low …

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