Accès ouvert
2025
article
OpenAlex
Hang Li, Gaohui Chen, Shiting Bao, Guotai Lin et autres
BACKGROUND: The relationship between the Advanced Lung Cancer Inflammation Index (ALI) and all-cause mortality in patients with Metabolic Dysfunction-Associated Steatohepatitis and Metabolic-Associated Alcoholic Liver Disease and other combination etiology of steatosis (MASLD/MetALD & Mixed Etiology Steatosis) is not well-understood. Current evidence is …
cn
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Accès ouvert
2024
article
OpenAlex
Rodica Pop‐Busui, Guillermo E. Umpierrez, WILLIAM C. BIGGS, Ian J. Orozco et autres
Importance: Continuous glucose monitoring (CGM) has been shown to be beneficial for adults with type 2 diabetes using intensive insulin therapy, but its use in type 2 diabetes treated with basal insulin without prandial insulin has not been well studied. Objective: To …
us
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Accès ouvert
2023
article
OpenAlex
Wei Dai, Shuo Fang, Cong Mo, Yuxin Liu et autres
BACKGROUND: This study compared the effectiveness and safety of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in the treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) involving specific sites. METHODS: This retrospective cohort study included patients with HBV-related HCC …
cn
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Accès ouvert
2022
article
OpenAlex
Bowen Yang, Tianning Sun, Yingle Chen, Hong‐Bing Xiang et autres
The pathogenesis of Hepatic Encephalopathy (HE) is complex and multifactorial. The development of metagenomics sequencing technology led to show the significant role of gut microbiota in the pathogenesis of cognitive dysfunction, which paved the way for further research in this field. However, …
cn, hk
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2018
article
OpenAlex
Chunqiang Zhong, Cong Mo, Runzhi Zhu, Bin Liu et autres
Objective To study the effect of JIB-04 on the proliferation and apoptosis of hepatocellular carcinoma (HCC) cells and the mechanism. Methods JIB-04, histone demethylase inhibitor, with different concentrations (0, 4, 8, 16 μmol/L) were used to treat hepatoma cells HepG2, QGY7701, QGY7703, …
cn
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2017
article
OpenAlex
Xiaojie Huang, Tianming Lian, Xiaoqian Guan, Bin Liu et autres
Natural antineoplastic drug development is crucial to treatment of clinical oncology. Dihydromyricetin, a bioactive flavonoid compound was extracted from the stems and leaves of Ampelopsis grossedentata. It exhibited anticancer activity and induced apoptosis in human hepatocellular carcinoma cells according to our previous …
cn
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Accès ouvert
2014
article
OpenAlex
Bin Liu, Wei Zhou, Xiaofeng Chen, Fengming Xu et autres
Dihydromyricetin (DHM) is a flavonoid compound which possesses potent antitumor activity. In the present study, it was demonstrated that DHM significantly inhibited proliferation and induced apoptosis in mouse hepatocellular carcinoma Hepal‑6 cells. Transforming growth factor β (TGF‑β) is recognized as a major …
cn
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Accès ouvert
2013
article
OpenAlex
Shixing Wu, Bin Liu, Qingyu Zhang, Jie Liu et autres
Dihydromyricetin (DHM) is a major active ingredient of flavonoids compounds. It exhibited anticancer activity and induced apoptosis in human hepatocellular carcinoma HepG2 cells according to our previous data. In this study, we investigated whether p53 is involved in DHM-triggered viability inhibition and …
cn
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2013
article
OpenAlex
Hui-kuan Chen, Shixing Wu, Shiting Bao
Objective To investigate the effects of silencing lysyl oxidase-like 2 protein (LOXL2)gene on pancreatic cancer cells.Methods LOXL2-short hairpin RNA (shRNA) plasmid was constructed by using lipofectamine,and transfected into pancreatic cancer Panc-1 cells.The changes of LOXL2 protein expression in pancreatic cancer panc-1 cells …
cn
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2013
article
OpenAlex
Zhong‐Kao Liu, Changjiang Lei, Zhidong Qiu, Mingyi Li et autres
Objective To research the effect of mir-520c-3p targeted GPC3 to the hepatocellular carcinoma Huh-7 cell proliferation,migration,and the influence of the attack ability and find new theoretical basis for liver hepatocellular carcinoma clinical treatment.Methods The cells were divided into three groups:not transfection of …
cn
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2013
article
OpenAlex
Huilai Miao, Changjiang Lei, Zhidong Qiu, Zhong‐Kao Liu et autres
AIM: Glypican-3 (GPC3) is a membrane-associated heparan sulfate proteoglycan involved in regulation of cell proliferation, cell survival, cell migration and differentiation process. MicroRNAs (miRNAs) are single-stranded, non-coding functional RNAs that are important in many biological processes. GPC3 and miRNAs have been found …
cn
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2012
article
OpenAlex
Wei Dai, Nianping Chen, Shiting Bao
Objective To observe the modulatory effects of saikosaponin-d (SSd) on the concentration of total bile acid (TBA),intracellular free calcium,and the expression of stromal interaction molecule 1 (STIM1) in the liver of rats with obstructive jaundice.Methods 108 male SD rats were randomly divided …
cn
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