Christy R. Grace

Midkine attenuates amyloid-β fibril assembly and plaque formation

Masihuz Zaman, Shu Yang, Ya Huang, Jay M. Yarbro et autres

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Structural basis of BAK sequestration by MCL-1 in apoptosis

G. Sekar, Adedolapo M. Ojoawo, Anup Aggarwal, Elisabeth Ferreira et autres

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Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

Masihuz Zaman, Shu Yang, Ya Huang, Jay M. Yarbro et autres

Abstract Proteomic profiling of Alzheimer’s disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the early disease stage, but their roles in disease progression are not fully understood. Here we present …

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Design of intrinsically disordered protein variants with diverse structural properties

Francesco Pesce, Anne Bremer, Giulio Tesei, Jesse B. Hopkins et autres

Intrinsically disordered proteins (IDPs) perform a broad range of functions in biology, suggesting that the ability to design IDPs could help expand the repertoire of proteins with novel functions. Computational design of IDPs with specific conformational properties has, however, been difficult because …

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Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

Junmin Peng, Masihuz Zaman, Shu Yang, Ya Huang et autres

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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

Tristen Wright, Meghan E. Turnis, Christy R. Grace, Xiao Li et autres

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The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer

Christopher D. Radka, Christy R. Grace, Hale S. Hasdemir, Yupeng Li et autres

Oleate hydratase (OhyA) is a bacterial flavoenzyme that catalyzes water addition to C-C double bonds of unsaturated fatty acids to produce hydroxylated fatty acids (hFA) (1). OhyA activity is an important step in the metabolic biotransformation of dietary linoleic acid by symbiotic …

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Design of intrinsically disordered protein variants with diverse structural properties

Francesco Pesce, Anne Bremer, Giulio Tesei, Jesse B. Hopkins et autres

Intrinsically disordered proteins (IDPs) perform a wide range of functions in biology, suggesting that the ability to design IDPs could help expand the repertoire of proteins with novel functions. Designing IDPs with specific structural or functional properties has, however, been difficult, in …

dk, us (code pays fourni par la source)

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

John A. Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia et autres

While heme synthesis requires the formation of a potentially lethal intermediate, protoporphyrin IX (PPIX), surprisingly little is known about the mechanism of its toxicity, aside from its phototoxicity. The cellular protein interactions of PPIX might provide insight into modulators of PPIX-induced cell …

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Abstract 1376: The carboxy terminus of oleate hydratase forms a membrane anchor that permits fatty acid acquisition from membranes

Christopher D. Radka, Christy R. Grace, Michael J. Oldham, Emad Tajkhorshid et autres

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

Francesco Pesce, Estella Anne Newcombe, Pernille Seiffert, Emil E. Tranchant et autres

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Small molecule SJ572946 activates BAK to initiate apoptosis

G. Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao et autres

Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them from globular dormant proteins to oligomers of the apoptotic pores. Small molecules …

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