Pernille Seiffert

The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Raul R. Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry et autres

Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prolactin receptor (PRLR), the role of lipids in …

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Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Yash Chhabra, Pernille Seiffert, Rachel S. Gormal, Manon Vullings et autres

Growth hormone (GH) acts via JAK2 and LYN to regulate growth, metabolism, and neural function. However, the relationship between these tyrosine kinases remains enigmatic. Through an interdisciplinary approach combining cell biology, structural biology, computation, and single-particle tracking on live cells, we find …

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Author response: The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Raul R. Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry et autres

The prolactin receptor, Janus kinase 2, and PI(4,5)P2 form a co-structure with the membrane resulting in orientations with different accessibility fixing the disordered juxtamembrane domain of the receptor in an extended structure.

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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

Francesco Pesce, Estella Anne Newcombe, Pernille Seiffert, Emil E. Tranchant et autres

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The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Raul R. Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry et autres

Abstract Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prolactin receptor (PRLR), the role of lipids …

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Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

Francesco Pesce, Estella Anne Newcombe, Pernille Seiffert, Emil E. Tranchant et autres

ABSTRACT Diffusion measurements by pulsed field gradient NMR and fluorescence correlation spectroscopy can be used to probe the hydrodynamic radius of proteins, which contains information about the overall dimension of a protein in solution. The comparison of this value with structural models …

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Tyrosine Kinases Compete for Growth Hormone Receptor Binding and Regulate Receptor Mobility and Degradation

Yash Chhabra, Pernille Seiffert, Rachel S. Gormal, Manon Vullings et autres

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Orchestration of signaling by structural disorder in class 1 cytokine receptors

Pernille Seiffert, Katrine Bugge, Mads M. Nygaard, Gitte W. Haxholm et autres

BACKGROUND: Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes such as proliferation, differentiation, immunity and growth through long disordered intracellular domains (ICDs), but …

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Orchestration of signaling by structural disorder in class 1 cytokine receptors

Pernille Seiffert, Katrine Bugge, Mads M. Nygaard, Gitte W. Haxholm et autres

Abstract Background: Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes such as proliferation, differentiation, immunity and growth through long disordered intracellular domains (ICDs), …

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Orchestration of signaling by structural disorder in class 1 cytokine receptors

Pernille Seiffert, Katrine Bugge, Mads M. Nygaard, Gitte W. Haxholm et autres

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Production of Intrinsically Disordered Proteins for Biophysical Studies: Tips and Tricks

Christian Parsbæk Pedersen, Pernille Seiffert, Inna Brakti, Katrine Bugge

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