Emmanuelle Landmann

SAT-086 Tumour-infiltrating regulatory T cells engage Nrf2 signalling to support their metabolic adaptation in hepatocellular carcinoma

Elena Perpiñán, Nicolas Sompairac, Erik Ramon Gil, R. A de Man et autres

SAT-509-YI Affinity-tuning chimeric antigen receptors could improve the therapeutic efficacy of regulatory t cells in liver transplantation

Ada Sera Kurt, Marwa Elgosbi, Emmanuelle Landmann, Elisavet Codela et autres

Conferring alloantigen specificity to regulatory T cells: A comparative analysis of cell preparations undergoing clinical development in transplantation

Ada Sera Kurt, Paula Ruiz, Emmanuelle Landmann, Marwa Elgosbi et autres

regulatory T cells (Tregs) increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. Three strategies are currently undergoing clinical development, which involve the following: (1) expanding Tregs in the presence of donor B cells (donor alloantigen-reactive [DAR] …

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Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore et autres

Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE), or chimeric antigen receptor (CAR) cells is very effective for hematologic diseases. Unlike the breakthrough progress achieved for B cell malignancies, there is …

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Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease

Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin Correa, Marco Romano et autres

BACKGROUND: Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation and maintain tissue homeostasis. While inflammatory cues are well known to …

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Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore et autres

Summary Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE) or chimeric antigen receptor (CAR) cells is very effective for haematologic diseases. Unlike the breakthrough progress achieved for B cell malignancies, there …

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Engineered Single Amino Acid Substitutions Protect Hematopoietic Stem and Progenitor Cells from CD123 Targeted Immunotherapy

Emmanuelle Landmann, Anna Devaux, Rosalba Lepore, Romina Marone et autres

Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), T cell engagers (TCE) or chimeric antigen receptor (CAR) cells is very effective for hematologic diseases. CD123, the interleukin-3 (IL-3) receptor alpha-chain, is highly expressed in various hematological malignancies, including …

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CRISPR/Cas-based Human T cell Engineering: Basic Research and Clinical Application

Bettina E. Bernard, Emmanuelle Landmann, Lukas T. Jeker, Kathrin Schumann

Engineering human T cells for the treatment of cancer, viral infections and autoimmunity has been a long-standing dream of many immunologists and hematologists. Although primary human T cells have been genetically engineered for decades, this process was challenging, time consuming and mostly …

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Verhinderung schwerer Nierenschädigung durch Pankreasenzymsubstitution?

Julian Amadeus Biggel, Emmanuelle Landmann, Argyrios Georgalis, Thomas Menter et autres

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Lactic acidosis and hyperlactatemia associated with lamivudine accumulation and sepsis in a kidney transplant recipient—a case report and review of the literature

Alexa Hollinger, Nadine Cueni, Catia Marzolini, Michael Dickenmann et autres

BACKGROUND: We report a case of sudden, lethal metabolic acidosis in a 70-year-old man on long-term nucleoside reverse transcriptase inhibitor (NRTI) -based antiretroviral therapy (ART) who had developed atypical necrotizing fasciitis 1 month after kidney transplantation. CASE PRESENTATION: The HIV infection of …

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Acute kidney injury in patients with COVID-19: a retrospective cohort study from Switzerland

Matthias Diebold, Stefan Schaub, Emmanuelle Landmann, Jürg U. Steiger et autres

BACKGROUND: Data about patients in Europe with corona virus disease-2019 (COVID-19) and acute kidney injury (AKI) are scarce. We examined characteristics, presentation and risk factors of AKI in patients hospitalised with COVID-19 in a tertiary hospital in Switzerland. METHODS: We reviewed health …

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Intratumorale T-Zell-Dysfunktion in einem murinen Pankreaskarzinommodell: Rolle von IL-1R- und IL-18R-Signalling

Veronika Theresa Lutz, Alina Hanlon, Emmanuelle Landmann, Meredith A. Buchholz et autres

Einleitung: Die intratumorale Dysfunktion von CD8 + zytotoxischen T-Zellen (CTL) ist durch Exhaustion-Phänomene gekennzeichnet. T cell exhaustion spielt zumindest in Subtypen des Pankreaskarzinoms eine wichtige Rolle. Ziele: Hier wird in einem Modell des adoptiven T-Zell-Transfers die Rolle der Zytokine IL-18 und IL-1β …