Yuping Cao

Phenome-Wide Association Study of P2RX7 Identifies Schizophrenia and Mood Disorders as Primary Associated Phenotypes

Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen (63682) et autres

Objectives: P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these as sociations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those …

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Modifications on histone tails in psychiatric disorders

Qiao Mao, Zhixiong Luo, Zongyang Yu, Bin Chen et autres

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Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes

Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen et autres

Objectives P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these associations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those most …

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Modifications on histone tails in psychiatric disorders.

Qiao Mao, Zhixiong Luo, Zongyang Yu, Bin Chen et autres

The present study provides a comprehensive introduction to the features of histone tails, including their length, subtypes, nomenclature, biological functions, and regulation, and systematically reviews their roles in psychiatric disorders. A literature search was conducted, covering over 200 common histone modifications and …

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A clinical prediction model for risk of depressive episode based on facial behavioral features: A cross-sectional study

Tingting Qu, Chennan Wang, Qiuquan Gu, Qi Wang et autres

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25-PUB: Descending Mode during Short-Term Intensive Insulin Therapy Achieved Lower Fasting Blood Glucose after Insulin Pump Suspension in Newly Diagnosed Patients with Type 2 Diabetes

Yuping Cao, Zhi Zhang, Yanbing Li, Zhimin Huang

Introduction and Objective: We have reported that newly diagnosed patients with T2DM receiving short-term intensive insulin therapy (SIIT) achieved drug-free remission, and that descending mode led to a higher percentage of time in range (3.9-10mmol/L, %TIR). Our objective was to explore whether …

The association between expressive suppression and anxiety in Chinese left-behind children in middle school: serial mediation roles of psychological resilience and self-esteem

Tingting Qu, Qiuquan Gu, Huan Yang, Chennan Wang et autres

BACKGROUND: Left-behind children (LBC) have become a special population to be concerned due to the negative consequences of parental absence during their physical and psychological development in China. Expressive suppression (ES) is a response-focused emotion regulation and may be frequently used by …

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Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU): Trial Satisfaction and Attitudes towards Future Clinical Trials

Haiyan Liu, Jonathan C. Li, Ellen Ziegemeier, Sarah Foster Adams et autres

BACKGROUND: Clinical trial satisfaction is increasingly important for future trial designs and is associated with treatment adherence and willingness to enroll in future research studies or to recommend trial participation. In this post-trial survey, we examined participant satisfaction and attitudes toward future …

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Assessing Gender Differences in Technological Pedagogical Content Knowledge (TPACK) among EFL High School Teachers in Inner Mongolia

Jinyao Li, Aruna Zhao, Yu Zhang, Yuping Cao

This study examines gender differences in Technological Pedagogical Content Knowledge (TPACK) among 437 English as a Foreign Language (EFL) high school teachers in Inner Mongolia, China. Quantitative data revealed significant TPACK disparities between male and female teachers, with males exhibiting higher levels. …

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A metabolomics perspective reveals the mechanism of the uric acid-lowering effect of Prunus salicina Lindl. cv. “furong” polyphenols in hypoxanthine and potassium oxybate-induced hyperuricemic mice

Li Wu, Kexin Yi, Zheng Xiao, Qing Xia et autres

< 0.05), wherein the maximum decrease rates are up to 44.50%, 29.46%, and 32.95%, respectively. PSLP are observed to exert a pronounced inhibitory effect on the activities of xanthine oxidase (XOD) and adenosine deaminase (ADA) in the livers of HUA mice, with …

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Hypoconnectivity within the cingulo‐opercular network in patients with mild cognitive impairment in Chinese communities

Huan Yang, Xiaoyu Zhao, Tenglong Wang, Zhenhe Zhou et autres

INTRODUCTION: At rest, the brain's higher cognitive systems engage in correlated activity patterns, forming networks. With mild cognitive impairment (MCI), it is essential to understand how functional connectivity within and between resting-state networks changes. This study used resting-state functional connectivity to identify …

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A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study

Xiaoyun Guo, Shibin Wang, Xiandong Lin, Zuxing Wang et autres

OBJECTIVES: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this risk gene, carefully investigated its novel risk variants for schizophrenia, and explored …

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