A metabolomics perspective reveals the mechanism of the uric acid-lowering effect of Prunus salicina Lindl. cv. “furong” polyphenols in hypoxanthine and potassium oxybate-induced hyperuricemic mice
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< 0.05), wherein the maximum decrease rates are up to 44.50%, 29.46%, and 32.95%, respectively. PSLP are observed to exert a pronounced inhibitory effect on the activities of xanthine oxidase (XOD) and adenosine deaminase (ADA) in the livers of HUA mice, with reductions of up to 16.36% and 20.13%, respectively. These findings illustrate that PSLP exert a significant uric acid-lowering effect. Subsequent metabolomic analysis of mouse serum identified 28 potential biomarkers for hyperuricemia, whose levels were markedly diminished by PSLP. This process involved alterations in purine, glycine, the pentose phosphate pathway, and galactose metabolism. Twenty-eight potential biomarkers were identified for hyperuricemia by subsequent metabolomic analysis of mouse serum, whose levels were markedly reversed by PSLP intervention. The regulation of HUA by PSLP involved alterations in purine metabolism, glycerolipid metabolism, the pentose phosphate pathway, and galactose metabolism. The mechanism of PSLP ameliorated hyperuricemia might be attributed to reduction of the level of the uric acid precursor ribose-5-phosphate in the pentose phosphate pathway, the inhibition of the activities of uric acid synthase XOD and ADA in purine metabolism, and reduction of the synthesis of the end product uric acid. This study provides a theoretical basis for the development of functional foods based on PSLP, which can potentially reduce uric acid levels.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- A metabolomics perspective reveals the mechanism of the uric acid-lowering effect of <i>Prunus salicina</i> Lindl. cv. “furong” polyphenols in hypoxanthine and potassium oxybate-induced hyperuricemic mice
- Date Crossref
- 01/01/2024
- Éditeur
- Royal Society of Chemistry (RSC)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute of Food Science and Technology pays non établi dans la noticeStructure de recherche
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Fujian Academy of Agricultural Sciences pays non établi dans la noticeStructure de recherche
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Ministry of Agriculture and Rural Affairs pays non établi dans la noticeOrganisme public
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Fujian Agriculture and Forestry University pays non établi dans la noticeUniversité ou école supérieure
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Fujian Province Key Laboratory of Agricultural Products (Food) Processing Technology pays non établi dans la noticeStructure de recherche
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Key Laboratory of Subtropical Characteristic Fruits pays non établi dans la noticeStructure de recherche
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National R & D Center for Edible Fungi Processing pays non établi dans la noticeInstitution
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College of Food Science pays non établi dans la noticeUniversité ou école supérieure
Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences et Ministry of Agriculture and Rural Affairs, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.