Hypoconnectivity within the cingulo‐opercular network in patients with mild cognitive impairment in Chinese communities
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Le résumé fourni par la source
INTRODUCTION: At rest, the brain's higher cognitive systems engage in correlated activity patterns, forming networks. With mild cognitive impairment (MCI), it is essential to understand how functional connectivity within and between resting-state networks changes. This study used resting-state functional connectivity to identify significant differences within and between the cingulo-opercular network (CON) and default mode network (DMN). METHODS: We assessed cognitive function in patients using the Chinese version of the Alzheimer's disease assessment scale-Cognitive subscale (ADAS-Cog). A group of MCI subjects (ages 60-83 years, n = 45) was compared to age-matched healthy controls (n = 70). Resting-state functional connectivity was used to determine functional connectivity strength within and between the CON and DMN. RESULTS: Compared to healthy controls, the MCI group showed significantly lower functional connectivity within the CON (F = 10.76, df = 1, p = 0.001, FDR adjusted p = 0.003). Additionally, the MCI group displayed no distinct differences in functional connectivity within DMN (F = 0.162, df = 1, p = 0.688, FDR adjusted p = 0.688) and between CON and DMN (F = 2.270, df = 1, p = 0.135, FDR adjusted p = 0.262). Moreover, we found no correlation between ADAS-Cog and within- or between-connectivity metrics among subjects with MCI. CONCLUSIONS: Our findings indicate that specific patterns of hypoconnectivity within CON circuitry may characterize MCI relative to healthy controls. This work improves our understanding of network dysfunction underlying MCI and could inform more targeted treatment.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hypoconnectivity within the cingulo‐opercular network in patients with mild cognitive impairment in Chinese communities
- Date Crossref
- 01/08/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Central South University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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National Clinical Research pays non établi dans la noticeStructure de recherche
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Second Xiangya Hospital of Central South University pays non établi dans la noticeÉtablissement de santé
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Wuxi People's Hospital pays non établi dans la noticeÉtablissement de santé
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
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Nanjing Medical University Wuxi Mental Health Center pays non établi dans la noticeUniversité ou école supérieure
Department of Psychiatry — Central South University, National Clinical Research et Second Xiangya Hospital of Central South University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.