25-PUB: Descending Mode during Short-Term Intensive Insulin Therapy Achieved Lower Fasting Blood Glucose after Insulin Pump Suspension in Newly Diagnosed Patients with Type 2 Diabetes

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Introduction and Objective: We have reported that newly diagnosed patients with T2DM receiving short-term intensive insulin therapy (SIIT) achieved drug-free remission, and that descending mode led to a higher percentage of time in range (3.9-10mmol/L, %TIR). Our objective was to explore whether it yielded lower fasting blood glucose (FBG) after SIIT, which has been proven to predict better long-term glycemic control. Methods: 1822 medical records were analyzed. They were categorized into descending or ascending groups according to Tmax shorter or longer than half the length of insulin pump treatment. Results: Patients in the descending group were younger, had higher BMI, with slightly lower fasting blood glucose before SIIT. The Tmax was shorter, total daily insulin dose was higher on the first day, whereas lesser on the day of maximum and pump suspension. Mean blood glucose was lower, and %TIR was higher in the descending group. FBG after pump suspension was significantly lower, while more patients achieved FBG <6.1mmol/L after pump suspension. Conclusion: The descending mode represents a more experienced insulin dose adjustment method, starting with a higher initial dose, while with lesser insulin dose on the day of maximum and pump suspension, achieves lower FBG after SIIT. Disclosure X. Zhang: None. X. Huang: None. Y. Cao: None. S. Liu: None. Z. Zhang: None. Y. Li: None. Z. Huang: None. Funding National Natural Science Fund of China (82070918)

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