Neale Scott Mason

Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

Jeffrey S. Stehouwer, Guofeng Huang, Dinahlee Saturnino Guarino, Manik L. Debnath et autres

Structure–activity relationship studies were performed on a library of synthesized compounds based on previously identified tau ligands. The top 13 new compounds had Ki values in the range of 5–14 nM in Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration …

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Assessing the efficacy of BETTH‐derived tau thresholds to predict cognitive decline in non‐demented individuals

Alexandra L. Gogola, Brian J. Lopresti, Beth Ellen Snitz, Dana Tudorascu et autres

Abstract Background Tau PET thresholds should detect early tau deposition and predict cognitive decline. We evaluated the relationships between the BETTH‐derived sensitivity and specificity tau thresholds (Gogola et al, doi:10.2967/jnumed.123.265941, 2023) and cognitive changes in non‐demented participants. Method FTP scans from 314 …

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Evaluating impact of racialization on imaging and plasma biomarkers

Alexandra L. Gogola, Xuemei Zeng, Anum Saeed, Brian J. Lopresti et autres

Abstract Background Imaging and plasma biomarkers are widely used in Alzheimer’s disease (AD) observational studies and clinical trials. Due to the lack of racial or ethnic diversity in earlier studies, a more complete understanding of biomarker differences across racialized groups is needed. …

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Assessing the correlations between imaging and plasma biomarkers within the AT(N) framework

Alexandra L. Gogola, Ann D. Cohen, Xuemei Zeng, Brian J. Lopresti et autres

Abstract Background Given the increasing usage of plasma biomarkers for Alzheimer’s disease (AD) studies, it is necessary to better understand relationships between plasma biomarker and PET and MR imaging outcomes, particularly within the AT(N) framework. Method We evaluated plasma samples from 233 …

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Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies

Alexandra L. Gogola, Ann D. Cohen, Beth Ellen Snitz, Davneet Singh Minhas et autres

Background: Tau accumulation in Alzheimer's disease is associated with short term clinical progression and faster rates of cognitive decline in individuals with high amyloid-β deposition. Defining an optimal threshold of tau accumulation predictive of cognitive decline remains a challenge. Objective: We tested …

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Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

Anton Lindberg, Emily Murrell, Junchao Tong, Neale Scott Mason et autres

Abstract Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for imaging non-AD tauopathies. Here we show …

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Kinetic modeling of the monoamine oxidase-B radioligand [ 18 F]SMBT-1 in human brain with positron emission tomography

Brian J. Lopresti, Jeffrey S. Stehouwer, Alexandria C. Reese, Neale Scott Mason et autres

This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [ 18 F]( S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline ([ 18 F]SMBT-1) for positron emission tomography (PET) brain imaging. Brain MAO-B expression is widespread, predominantly within astrocytes. Reactive astrogliosis in response to neurodegenerative disease pathology is associated …

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First-In-Class Diagnostics Targeting Neuropeptide Y1 Receptor (Y1R): Enabling Molecular Imaging of Metastatic Breast Cancer

Marwa Nadia Rahimi, Jessica Van Zuylekom, Neale Scott Mason, Benjamin J. Blyth et autres

[18F]OXD-2314: A 4R-Tau PET Radiotracer with Improved Affinity and Brain Uptake

Neale Scott Mason, Anton Lindberg, Daniel Sohn, Johan Sandell et autres

Biostatistical Estimation of Tau Threshold Hallmarks (BETTH) Algorithm for Human Tau PET Imaging Studies

Alexandra L. Gogola, Brian J. Lopresti, Dana Tudorascu, Beth Ellen Snitz et autres

A methodology for determining tau PET thresholds is needed to confidently detect early tau deposition. We compared multiple threshold-determining methods in participants who underwent either 18F-flortaucipir or 18F-MK-6240 PET scans. Methods:18F-flortaucipir (n = 798) and 18F-MK-6240 (n = 216) scans were processed …

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Traits and Trammels of Tau Tracer Imaging

Victor L. Villemagne, Brian J. Lopresti, Vincent Doré, Davneet Singh Minhas et autres

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Evaluation of A Direct Regional Reprojection Reconstruction Method to Improve Quantitation of Amyloid and Tau PET Images using 3D Printed Phantoms

Emily E. Meehan, Davneet Singh Minhas, Alexandra L. Gogola, Anish G. Ghodadra et autres

Abstract Background Image reconstruction and partial volume correction (PVC) techniques designed to account for the limited spatial resolution of PET are used inconsistently in amyloid and tau PET imaging, likely due to a lack of characterization of the techniques and their unknown …

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