Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies
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Le résumé fourni par la source
Background: Tau accumulation in Alzheimer's disease is associated with short term clinical progression and faster rates of cognitive decline in individuals with high amyloid-β deposition. Defining an optimal threshold of tau accumulation predictive of cognitive decline remains a challenge. Objective: We tested the ability of regional tau PET sensitivity and specificity thresholds to predict longitudinal cognitive decline. We also tested the predictive performance of thresholds in the proposed new NIA-AA biological staging for Alzheimer's disease where multiple levels of tau positivity are used to stage participants. Methods: 18F-flortaucipir scans from 301 non-demented participants were processed and sampled. Four cognitive measures were assessed longitudinally. Regional standardized uptake value ratios were split into infra- and suprathreshold groups at baseline using previously derived thresholds. Survival analysis, log rank testing, and Generalized Estimation Equations assessed the relationship between the application of regional sensitivity/specificity thresholds and change in cognitive measures as well as tau threshold performance in predicting cognitive decline within the new NIA-AA biological staging. Results: The meta temporal region was best for predicting risk of short-term cognitive decline in suprathreshold, as compared to infrathreshold participants. When applying multiple levels of tau positivity, each subsequent level of tau identified cognitive decline at earlier timepoints. Conclusions: When using 18F-flortaucipir, meta temporal suprathreshold classification was associated with increased risk of cognitive decline, suggesting that abnormal tau deposition in the cortex predicts decline. Likewise, the application of multiple levels of tau clearly predicts the distinctive cognitive trajectories in the new NIA-AA biological staging framework.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies
- Date Crossref
- 20/08/2024
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Pittsburgh Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Geriatric Research Education and Clinical Center pays non établi dans la noticeÉtablissement de santé
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Commonwealth Scientific and Industrial Research Organisation pays non établi dans la noticeOrganisme public
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CSIRO Health and Biosecurity pays non établi dans la noticeStructure de recherche
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Austin Health pays non établi dans la noticeÉtablissement de santé
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Critical Path Institute Critical Path for Alzheimer’s Disease (CPAD) Consortium pays non établi dans la noticeOrganisation à but non lucratif
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Department of Molecular Imaging & Therapy pays non établi dans la noticeInstitution
Department of Radiology — University of Pittsburgh, Geriatric Research Education and Clinical Center et Commonwealth Scientific and Industrial Research Organisation, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.