Yong-Han Hong

Allophycocyanin enhances myogenic differentiation and reverses canagliflozin-induced inhibition in C2C12 myoblasts

Chi-Hsien Huang, Tzyh-Chyuan Hour, Nguyen Kieu Linh, Yong-Han Hong et autres

Canagliflozin (CANA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor widely prescribed for type 2 diabetes, has been reported to impair skeletal muscle regeneration and differentiation. This study investigated the potential effect of allophycocyanin (APC), a phycobiliprotein found in cyanobacteria such as Spirulina platensis, …

Effects of Fermentation and Oxidative Degradation on the Composition, Antioxidant Activity, ACE Inhibitory Activity, and In Vitro Neuroprotective Potential of Soybean-Derived Kefir Polysaccharide-Rich Extracts

Wei-Cheng Hsiao, Taiki Miyazawa, Sue‐Joan Chang, Yong-Han Hong et autres

Kefir is a probiotic beverage produced by symbiotic bacteria and yeasts. Polysaccharide-rich extracts from yellow and black soybeans (S and B) were obtained and subsequently fermented to produce S-F and B-F. The fermented extracts were further subjected to oxidative degradation using ascorbic …

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Preparation of Various Glycoside Hydrolase Enzyme Extracts from Durvillaea antarctica and Evaluation of the Neuroprotective Efficacy

Wei-Cheng Hsiao, Tien-Chiu Wu, Yong-Han Hong, Mei-Chun Lin et autres

In this study, three distinct hydrolysates, which are designated Dur-I, Dur-II, and Dur-III, were generated from extrusion-pretreated Durvillaea antarctica biomass by applying viscozyme, cellulase, and α-amylase, respectively. Chemical analyses demonstrated distinct compositional differences among the extracts, whereas FTIR spectra verified the presence …

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Unprecedented rearranged triterpenoids with seven-membered rings from Camellia formosensis and structurally diverse bioactive triterpenoids

S Li, Yong-Han Hong, Tsong‐Long Hwang, Chia-Hung Yen et autres

Triterpenoids from Camellia formosensis leaves exhibit integrated therapeutic potential as natural anti-inflammatory candidates for treating diverse inflammatory disorders.

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Rice Husk Silica Liquid Enhances Autophagy and Reduces Overactive Immune Responses via TLR-7 Signaling in Lupus-Prone Models

Chieh Kao, Shih‐Wei Wang, Po-Chun Chen, Chun-Yung Huang et autres

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread inflammation and multi-organ damage. Toll-like receptor 7 (TLR-7) and autophagy have been implicated in SLE pathogenesis. Rice husk silica liquid (RHSL) has shown potential for modulating inflammatory responses, but its …

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Rice Husk Silica Liquid Enhances Autophagy and Reduces Overactive Immune Responses via TLR-7 Signaling in Lupus-Prone Models

Chieh Kao, Shih‐Wei Wang, Po‐Chun Chen, Chun-Yung Huang et autres

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread inflammation and multi-organ damage. Toll-like receptor 7 (TLR-7) and autophagy have been implicated in SLE pathogenesis. Rice husk silica liquid (RHSL) has shown potential for modulating inflammatory responses, but its …

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Anti-Inflammatory and T-Cell Immunomodulatory Effects of Banana Peel Extracts and Selected Bioactive Components in LPS-Challenged In Vitro and In Vivo Models

Yong-Han Hong, Chieh Kao, Chi‐Chang Chang, Fu-Kuei Chang et autres

Banana peel (BP) has potent antioxidative properties; however, the anti-inflammatory potential of BP and its related bioactive components remain unclear. This study used solvent extraction and gas chromatography–mass spectrometry (GC–MS) to isolate and identify the active fractions and compounds in BP. BP …

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Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo

Hsin-Yuan Chen, Yi‐Fen Chiang, Yong-Han Hong, Tzong‐Ming Shieh et autres

Lupus nephritis (LN) is a common and serious symptom in patients with systemic lupus erythematosus (SLE). Tubular interstitial fibrosis is a common underlying mechanism in the development of lupus nephritis to end-stage renal failure (ESRD). Quercetin is widely proven to prevent tissue …

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Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice

Hsin-Yuan Chen, Yong-Han Hong, Yi‐Fen Chiang, Kai-Lee Wang et autres

Type 2 diabetes mellitus is a complex multifactorial disease characterized by poor glucose tolerance and insulin resistance. Rice-husk silica liquid (RHSL) derived from rice husk has the ability to improve the dysfunction of pancreatic β-cells. This study aimed to confirm the potential …

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Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway

Y-H. Chen, Yi‐Fen Chiang, Chun-Yung Huang, Tzong‐Ming Shieh et autres

Metastasis is a major challenge in aggressive endometrial cancer treatment accounting for the high recurrence risk and poor prognosis of epithelial-mesenchymal transition (EMT), regulated by the transforming growth factor beta (TGFβ) signaling pathway, facilitates tumor metastasis. Spirulina phycocyanin extract (SPE) and its …

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The Role of Cell Proliferation and Extracellular Matrix Accumulation Induced by Food Additive Butylated Hydroxytoluene in Uterine Leiomyoma

Yi‐Fen Chiang, Y-H. Chen, Mohamed K. Ali, Tzong‐Ming Shieh et autres

Leiomyoma is the most common benign uterine tumor in reproductive-age women. Increasing numbers of studies are focusing on the effects of environmental exposure on the incidence and progression of tumors. One major step taken in the food industry is the addition of …

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Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE)

Y-H. Chen, Wen-Pin Cheng, Yi‐Fen Chiang, Yong-Han Hong et autres

Hinokitiol is a natural tropolone derivative that is present in the heartwood of cupressaceous plants, and has been extensively investigated for its anti-inflammatory, antioxidant, and antitumor properties in the context of various diseases. To date, the effects of hinokitiol on endometrial cancer …

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