Tsong‐Long Hwang

Acrolein- thioredoxin 1- p38 signaling drives neutrophil-mediated immunosuppression and glioblastoma progression

Zhen-Jie Tong, Tsong‐Long Hwang, Kuo‐Chen Wei, Chiung-Yin Huang et autres

Glioblastoma (GBM) is a highly aggressive type of brain tumor characterized by diffuse infiltration and a profoundly immunosuppressive microenvironment in which polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) derived from neutrophils play a key role. In this study, we investigated how acrolein, a reactive …

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Natural Product‐Derived Vesicles in Nanotherapeutics

Kartiko Arif Purnomo, Tsong‐Long Hwang

Natural product-derived vesicles (NPVs) are lipid bilayer-enclosed nanovesicles isolated from diverse sources, including plants, fungi, and marine organisms, and are increasingly recognized as an emerging class of extracellular vesicles with potential therapeutic relevance. Their abundance, renewability, and capacity to transport endogenous metabolites …

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Discovery of VEGFR‐2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis

Thiyagarajan Raviraj, Chen‐Lin Yu, Aekkhaluck Intharuksa, Shang‐Chih Lai et autres

Angiogenesis, regulated by vascular endothelial growth factor (VEGF), is crucial in tumor growth, metastasis, and inflammation. Leonurus japonicus Houtt., a traditional Chinese herb, was investigated for its anti-angiogenic potential. DNA sequencing confirmed its identity, distinguishing it from the common morphological misidentification with …

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Therapeutic Potential of Salvia miltiorrhiza in Glioblastoma: Evidence from in vitro and in vivo Studies

C B Lee, Woon‐Man Kung, Yuan-Chieh Yeh, YR Chen et autres

Background: Glioblastoma (GB) is a highly aggressive and invasive brain tumor characterized by a poor prognosis. The Danshen ( Salvia miltiorrhiza Bunge) crude extract (DCE) demonstrated effective anticancer effects against glioblastoma. This study investigated the in vitro and in vivo efficacy of …

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Benzothiophene nucleus in target-directed anti-cancer drug discovery

Patrick M. Maximous, Michael Emad, Parthiena M Keddis, Ahmed K. ElHady et autres

The benzo[b]thiophene scaffold has emerged as a privileged chemotype in target-directed anticancer drug discovery because of its structural versatility and distinctive sulfur-centered interactions that support selective target binding. This review provides a focused, mechanism-based analysis of benzothiophene derivatives developed as anti-cancer agents, …

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Antigen-presenting neutrophils link streptococcal infection to adaptive immune activation in guttate psoriasis

Arpita Das, Tsong‐Long Hwang

Guttate psoriasis (GP) is a distinct clinical variant of psoriasis characterized by the abrupt eruption of numerous small erythematous plaques, frequently occurring after streptococcal pharyngitis.1 Although the association between Group A Streptococcus (GAS) infection and GP onset has long been recognized, the …

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Bioactivity and in silico insights into 2-(2-phenylethyl)-4H-chromen-4-one and sesquiterpenoid constituents from agarwood (Aquilaria sinensis) as anti-inflammatory agents

Sin-Ling Wang, Sin‐Min Li, Tsong‐Long Hwang, Mei‐Ing Chung et autres

This study successfully isolated three new compounds and 13 known compounds ( 3 and 5 – 16 ) from the agarwood of Aquilaria sinensis . Among them, compounds 2 , 3 , 5 , 8 , 13 , and 16 exhibited inhibitory …

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A Feasible Method of Reducing Carbon Emission for Processing Traditional Chinese Medicine

Haoze Li, Hồng Nhung Phan, Chia-Hung Wu, Yi-Hung Wu et autres

Objective Traditional Chinese medicine processing typically employs a significant amount of water and heat, and thus is classified as an environmentally unfriendly process. Additionally, diverse processing methods will produce variations in composition and content among the products, resulting in inconsistent quality. The …

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Dual inhibition of neutrophil superoxide generation and elastase release via JNK, ERK and FAK pathways: blockade by methoxy-chalcone derivatives

Dalia S. El‐Gamil, Mennatallah A. Hammam, Michael Emad, Donia E. Hafez et autres

= 2.63 µM) with minimal elastase impact. Compound 17 hampered neutrophil migration without inducing cytotoxicity, and mechanistically inhibited the phosphorylation of JNK, ERK, and FAK/paxillin-key signaling pathways in neutrophil migration and activation, without altering calcium flux. These findings highlight compound 17 as …

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List of contributors

Ashraf H. Abadi, Abdelrahman M. Abdelfattah, Mohammad Abdel-Halim, Yousef A. Abdul Qader et autres

Splicing kinases in neuronal health and neurodegeneration

Dalia S. El‐Gamil, Michael Emad, Sarah S. Darwish, Tsong‐Long Hwang et autres

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Unprecedented rearranged triterpenoids with seven-membered rings from Camellia formosensis and structurally diverse bioactive triterpenoids

S Li, Yong-Han Hong, Tsong‐Long Hwang, Chia-Hung Yen et autres

Triterpenoids from Camellia formosensis leaves exhibit integrated therapeutic potential as natural anti-inflammatory candidates for treating diverse inflammatory disorders.

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