Po-Chun Chen

High-intensity thermal stress enhances adoptive NK-cell cytotoxicity in poorly differentiated hepatocellular carcinoma

Po-Chun Chen, Janet Pham, Sara Huerta‐Yépez, Tiran Sargsyan et autres

Background Percutaneous thermal ablation is used to treat early-stage, non-resectable hepatocellular carcinoma (HCC). NK-cell immunotherapy has been studied as an adjuvant treatment, but the efficacy remains unclear when combined with ablation.Purpose To evaluate the potential of peri-ablational, high-intensity thermal stress to augment …

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Site-Specific Native Antibody-Conjugated Microbubbles for Molecular Ultrasound Imaging of Hepatocellular Carcinoma

James Z. Hui, Yonghwan Shin, Janet Pham, Po-Chun Chen et autres

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Therapeutic Efficacy of CD34-Derived Allogeneic Dendritic Cells Engineered to Express CD93, CD40L, and CXCL13 in Humanized Mouse Models of Pancreatic Cancer

Sara Huerta‐Yépez, Jose D. Gonzalez, Neha Sheik, Elango Kathirvel et autres

Background/Objectives: Pancreatic cancer remains the fourth leading cause of cancer-related deaths. While peripheral blood-derived mature dendritic cell (mDC) vaccines have shown potential in eliciting anti-tumor immune responses, clinical efficacy has been limited. This study aimed to enhance the potency and scalability of …

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Osteoclast-expanded supercharged NK cells perform superior antitumour effector functions

Meng-Wei Ko, Ao Mei, Emanuela Senjor, Milica Perišić Nanut et autres

Objective: Natural killer (NK) cells are the largest innate lymphocyte subset with potent antitumour and antiviral functions. However, clinical utilisation of human NK cells is hampered due to a lack of reliable methods to augment their antitumour potential. We demonstrated technology in …

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Galectin-1 modulates glycolysis through a GM1-galactose–dependent pathway to promote hyperthermia resistance in HCC

Tu Anh Nguyen, Yonghwan Shin, Aravinth Ruppa, Abigail S. Krall et autres

BACKGROUND AND AIMS: Thermal ablation is the standard-of-care treatment modality with curative intent for early-stage nonresectable HCC, but a durable response is limited, with up to 40% of patients with HCC eventually experiencing local recurrence on posttreatment surveillance. While thermal ablation has …

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Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression

Sara Huerta-Yepez, Po-Chun Chen, Kawaljit Kaur, Yash Jain et autres

Objective To demonstrate the significance of supercharged natural killer (sNK) cells to target aggressive gynecological tumours. Methods and analysis We used cell cultures of peripheral blood-derived mononuclear cells (PBMCs) and purified NK cells alone and in the presence of tumours. MHC-class gene …

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TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D

Po-Chun Chen, Katja Deterding, Sophie Anna Engelskircher, Kerstin Port et autres

BACKGROUND AND AIMS: Bulevirtide (BLV) is a novel and the only approved treatment option for patients with chronic hepatitis D (CHD). BLV alleviates liver inflammation early during treatment when only minor HDV RNA changes are observed. We hypothesized that BLV treatment may …

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Supercharged NK cells: A Novel NK cell-based Immunotherapy to Target poorly differentiated and well-differentiated Uterine Cancers

Edward Sher, Sara-Huerta Yepez, Po-Chun Chen, Anahid Jewett et autres

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Rice Husk Silica Liquid Enhances Autophagy and Reduces Overactive Immune Responses via TLR-7 Signaling in Lupus-Prone Models

Chieh Kao, Shih‐Wei Wang, Po-Chun Chen, Chun-Yung Huang et autres

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread inflammation and multi-organ damage. Toll-like receptor 7 (TLR-7) and autophagy have been implicated in SLE pathogenesis. Rice husk silica liquid (RHSL) has shown potential for modulating inflammatory responses, but its …

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Impending HCC diagnosis in patients with cirrhosis after HCV cure features a natural killer cell signature

Sophie Anna Engelskircher, Po-Chun Chen, Benedikt Strunz, Carlos Oltmanns et autres

BACKGROUND AND AIMS: The risk of developing HCC in chronically infected patients with AQ2 HCV with liver cirrhosis is significantly elevated. This risk remains high even after a sustained virological response with direct-acting antivirals. To date, disease-associated signatures of NK cells indicating …

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Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma

Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur et autres

Natural killer (NK) cells are innate lymphoid cells that exhibit high levels of cytotoxicity against NK-specific targets. NK cells also produce various cytokines, and interact with T cells, B cells, and dendritic cells to effectively serve as frontliners of the innate immune …

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Characterizing hepatocellular carcinoma stem markers and their corresponding susceptibility to NK-cell based immunotherapy

Jason Chiang, Po-Chun Chen, Janet Pham, Cat-Quynh Nguyen et autres

Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is the fourth-leading cause of all cancer-related deaths around the world. Liver transplantation, surgery, and local ablation are curative therapies for early-stage HCC. However, post-treatment outcomes can vary based on …

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