Xueyi Weng

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Danwen Zheng, Shiteng Cai, Jian Gao, Sheng Zhao et autres

ABSTRACT Atherosclerosis is a chronic inflammatory disease characterized by defective efferocytosis, which contributes to necrotic core expansion and plaque instability. This dysfunction arises from two key barriers: first, impaired recognition of apoptotic cells due to activation of the CD47–SIRPα immune checkpoint; and …

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A bio-inspired synthetic efferocytosis chimeric receptor restores macrophage efferocytosis and inflammatory resolution after cardiac injury

Zheyong Huang, Xueyi Weng, Haipeng Tan, Weiyan Li et autres

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Abstract 4368865: Ly6C-Targeted LNP Delivery of CAR-ABCA1 mRNA Reprograms Macrophages for Enhanced Efferocytosis and Cholesterol Efflux in Atherosclerosis

Weiyan Li, Xueyi Weng, Juying Qian

Introduction: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid accumulation and defective clearance of apoptotic cells in plaques. Traditional LDL-C-lowering therapies such as statins show limited efficacy, as they fail to correct underlying metabolic imbalances. These imbalances cause anti-inflammatory macrophages …

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Abstract 4362785: In vivo generation of CAR-M via LNP-mRNA targeting macrophages for immunotherapy in cardiac repair

Xueyi Weng

Background: Inflammatory response is a crucial mechanism in the development and progression of heart failure following ischemic cardiac injury, partly because the delayed clearance of apoptotic cells triggers excessive inflammation. Under normal circumstances, efferocytosis by macrophages mediates the active removal of apoptotic …

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Synergistic enhancement of efferocytosis and cholesterol efflux via macrophage biomimetic nanoparticle to attenuate atherosclerosis progression

Shiteng Cai, Jinfeng Gao, Xueyi Weng, Zhengmin Wang et autres

Atherosclerosis is the leading cause of myocardial infarction and stroke, which is characterized as a chronic inflammatory disease due to the aberrant accumulation of apoptotic cells in the necrotic core. Previous CD47-SIRPα checkpoint blockage strategies based on monoclonal antibodies or nanoparticles have …

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Engineered macrophage membrane fusion liposomes carrying siRNA for spatiotemporal regulation of the CCL2/CCR2 axis for cardiac repair

Xueyi Weng, Weiyan Li, Haipeng Tan, Zhiqing Pang et autres

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Association Between Patient and System Delays and In-Hospital Mortality in Primary PCI for STEMI: Findings from a Large, Nationwide Inpatients Sample

Hongbo Yang, Lingfeng Luo, Zheyong Huang, Yanan Song et autres

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Biomimetic Nano‐Degrader Based CD47‐SIRPα Immune Checkpoint Inhibition Promotes Macrophage Efferocytosis for Cardiac Repair

Jinfeng Gao, Zhiqing Pang, Qiaozi Wang, Yiwen Tan et autres

CD47-SIRPα axis is an immunotherapeutic target in tumor therapy. However, current monoclonal antibody targeting CD47-SIRPα axis is associated with on-target off-tumor and antigen sink effects, which significantly limit its potential clinical application. Herein, a biomimetic nano-degrader is developed to inhibit CD47-SIRPα axis …

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Genetically Engineered Macrophages Co‐Loaded with CD47 Inhibitors Synergistically Reconstruct Efferocytosis and Improve Cardiac Remodeling Post Myocardial Ischemia Reperfusion Injury

Haipeng Tan, Weiyan Li, Zhiqing Pang, Xueyi Weng et autres

Efferocytosis, mediated by the macrophage receptor MerTK (myeloid-epithelial-reproductive tyrosine kinase), is a significant contributor to cardiac repair after myocardial ischemia-reperfusion (MI/R) injury. However, the death of resident cardiac macrophages (main effector cells), inactivation of MerTK （main effector receptor), and overexpression of "do …

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Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction

Jinfeng Gao, Wusiman Yakufu, Hongbo Yang, Yanan Song et autres

Activation of the local renin–angiotensin system (RAS) promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction (AMI). As an anti-RAS drug, the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the …

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Checkpoint Nano-degrader to Transiently Promote Efferocytosis in Acute Myocardial Infarction

Jinfeng Gao, Zheyong Huang, Qiaozi Wang, Qiyu Li et autres

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The Peripandemic Impact of the First Wave of the COVID-19 Pandemic on Management and Prognosis of ST-Segment Elevation Myocardial Infarction in China

Hongbo Yang, Lingfeng Luo, Jiatian Cao, Yanan Song et autres

BACKGROUND: Rapid reperfusion of ST-segment elevation myocardial infarction (STEMI) has been challenging during the coronavirus disease 2019 (COVID-19) outbreak. Whether and to what degree there will be a residual impact when the COVID-19 pandemic has passed is unclear. METHODS: This nationwide retrospective …

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