Weiyan Li

miR-4652-5p targets GFPT1 to suppress ATF6-mediated unfolded protein response (UPR) and UPR-driven apoptosis to drive gastric tumor progression

Qingyu Zeng, Y N Huang, Liping Li, Shihao Liang et autres

The equilibrium of the endoplasmic reticulum (ER) is vital for ensuring regular cellular operations. However, diverse pathological stimuli can disrupt ER proteostasis, leading to ER stress and ultimately triggering programmed cell death. Ongoing stress in the ER activates the unfolded protein response …

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Intestinal metastases diffused from primary gastric adenocarcinoma with signet ring cells: case report

Haiping Qi, Weiyan Li, Luo Xingting, Bin Huang et autres

Signet ring cell carcinoma (SRCC), a poorly differentiated subtype of gastric adenocarcinoma, is known for its high metastatic capacity. However, metastases to the intestines, both small and large, are uncommon. This report describes a unique case of gastric adenocarcinoma with signet ring …

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A narrow-bandgap organic photothermal material enabling efficient solar driven sustainable electricity-water cogeneration

Xiaoqing Liu, Bingpeng Guo, Rui Wei, Huijun Kong et autres

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Self-Powered Ultraviolet Photodetectors Based on In Situ Growth Position-Controllable ZnO@Zn 3 (HHTP) 2 Core–Shell Arrays

Yanyao Chen, Yingtian Xu, Heng Liu, He Zhang et autres

Conjugated conductive metal-organic frameworks (MOFs) have garnered widespread attention in the field of optoelectronics due to their excellent electrical conductivity and unique porous structures. Currently, the interaction between MOF materials and semiconductors predominantly relies on van der Waals forces, which weaken the …

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A mechanistic study revealing that SLCO1B3 promotes gastric cancer development and metastasis through MAP1S expression downregulation

Shihao Liang, Yan Huang, Liping Li, Qingyu Zeng et autres

BACKGROUND: Gastric cancer (GC) remains a significant cause of mortality worldwide. Exploring the pathogenesis of GC is crucial for developing new therapeutic strategies. METHODS: Clinical sample sequencing and immunohistochemical analyses were employed to investigate the expression patterns of solute carrier organic anion …

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Gaps in BRCA mutation testing among mCRPC patients: Insights from US cancer practices (2018–2024).

Rana R. McKay, Weiyan Li, James P. Roose, Brendan T Kerr et autres

102 Background: Treatment of metastatic castration-resistant prostate cancer (mCRPC) has advanced with the approval of poly(ADP-ribose) polymerase inhibitor monotherapy and in combination with androgen receptor pathway inhibitor for patients (pts) with specific homologous recombination repair gene mutations, including BRCA mutations (BRCAm). Access …

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Sequencing of therapeutic agents before and after metastatic castration-resistant prostate cancer (mCRPC) diagnosis in an international real-world setting.

Rana R. McKay, Dana E. Rathkopf, Deborah Enting, Aurelius Gabriel Omlin et autres

100 Background: Over the last decade, many new approaches to mCRPC management have evolved. However, information is lacking on sequencing of active agents used pre- and post-mCRPC diagnosis in an international setting. In this real-world evidence study, we utilized an international registry …

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A bio-inspired synthetic efferocytosis chimeric receptor restores macrophage efferocytosis and inflammatory resolution after cardiac injury

Zheyong Huang, Xueyi Weng, Haipeng Tan, Weiyan Li et autres

cn, fr (code pays fourni par la source)

Spiderweb-inspired flextensional transduction enables giant piezoelectric response for monitoring imperceptible biomechanical signals

Shengjie Liu, Minqi Chen, Zhongqian Song, Weiyan Li et autres

Accurate monitoring biomechanical signals is critical for physiological assessment and clinical interventions, but remains challenging due to their dynamic and imperceptible characteristics. Here, inspired by the spiderweb’s ability to perceive weak mechanical perturbations, we present a flextensional transduction strategy that allows piezoelectric …

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Cultural Gene Mining and Green Communication Pathways of Ethnic Music from a Digital Humanities Perspective

Wangshu Zhang, Weiyan Li

This study focuses on the extraction of ethnic music cultural genes and green communication pathways from a digital humanities perspective. Addressing the digital transformation challenges faced by traditional ethnic music preservation, the study constructed a multimodal cultural gene extraction framework integrating deep …

Pacinian Corpuscle‐Inspired Strain Conversion Enables Ultrasensitive, Linear, and Broad‐Range Piezoelectric Sensing for Cardiovascular Health Monitoring

Qi Yang, Zhongqian Song, Shengjie Liu, Yingming Ma et autres

ABSTRACT High‐fidelity wrist pulse acquisition, essential for the early diagnosis and precise management of cardiovascular diseases, requires tactile sensors with both ultrasensitive and linear electromechanical responses. Biological Pacinian corpuscles transduce mechanical stimuli into localized strain via concentric lamellar architecture, enabling subtle and …

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Surface-confined metallization of nanofibrous networks via selective dissolution-assisted transfer printing for lightweight and air-permeable soft electronics

Weiyan Li, Zhongqian Song, Xiyue Zhang, Huijun Kong et autres

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