Juying Qian

Glycemic Control Impacts Plaque Progression in Premature Coronary Artery Disease: A Longitudinal CCTA Analysis

Qiyu Zhang, Jinying Zhou, Jingpu Wang, Fang Zhang et autres

cn (code pays fourni par la source)

Clinical Trail Design of [18F]XTR004 PET MPI for Detecting of Flow-Limiting Stenosis in Subjects with Suspected or Known CAD: a Phase III, Prospective, Multicenter Study in China

Li Huo, Jianming Li, Hongzhi Mi, Fugeng Liu et autres

cn, us (code pays fourni par la source)

Balloon-integrated binary acoustic lens for energy localisation in ultrasound renal denervation

Wanjin Zhao, Yizhe Wu, Ji M, Li Shen et autres

Background Renal denervation (RDN) is an established catheter-based therapy for resistant hypertension. However, its efficacy remains limited by inconsistent thermal injury to deep perivascular sympathetic nerves while preserving the renal arterial wall. Although ultrasound-based RDN systems using tubular transducers enable circumferential ablation, …

cn (code pays fourni par la source)

Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation

Su Li, Hexi Zhang, Muyin Liu, Wentao Zhu et autres

BACKGROUND: Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low-grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finerenone confers cardio-renal protection in diabetic settings, yet its underlying mechanisms remain incompletely defined. AIM: To explore the beneficial effects …

cn (code pays fourni par la source)

SGLT2 Inhibitors Attenuate Neutrophil-Mediated Endothelial Injury in Coronary Artery Disease With Type 2 Diabetes Mellitus Through a GREM1-Associated Smad Signaling Axis

W Y Zheng, Yi Zhou, Bozhi Ye, Shiyu Hu et autres

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a critical risk factor for coronary artery disease (CAD), with neutrophils contributing to CAD through acute inflammatory responses. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors offer cardiovascular benefits beyond glycemic control, but their mechanisms involving innate immunity …

cn (code pays fourni par la source)

Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets

Pingjing Zheng, Wendi Yan, Yang-Nan Ding, Yang Zhang et autres

Cardiovascular disease (CVD) predominantly affects elderly individuals and is the leading cause of morbidity, disability, and mortality worldwide. Systemic ageing, especially cardiovascular ageing, contributes to the development of CVD phenotypes and outcomes. Therefore, in this review, we innovatively summarize the five major …

cn, us, bg (code pays fourni par la source)

GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization

Yiqing Hu, Yongchao Zhao, Neng Li Dai, You Zhou et autres

BACKGROUND AND AIMS: Glucagon-like peptide-1 receptor agonists reduce heart failure (HF) risk in patients with diabetes or obesity. However, the extent to which this reduced risk is dependent on, or extends beyond, glucose control and weight reduction remains unclear. METHODS: Two-sample cis-Mendelian …

cn, gb, us (code pays fourni par la source)

Efficacy and safety of bevifibatide in patients with acute coronary syndrome undergoing percutaneous coronary intervention (BES-PCI): A multicenter, randomized, double-blinded, placebo-controlled, phase III trial

Hongyi Wu, Lili Xu, Lilian Bao, Zhifeng Yao et autres

Glycoprotein (GP) IIb/IIIa receptor inhibitors have been demonstrated to protect against ischemic complications of percutaneous coronary intervention (PCI) and improve the clinical outcomes of acute coronary syndrome (ACS). Recent guidelines recommend the use of a GP IIb/IIIa inhibitor when there is evidence …

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PIEZO1 gain-of-function mutation drives cardiomyopathy by disrupting myocardial lipid homeostasis besides iron overload

Cuiqin Fan, Han Du, Song Sun, Huixia Lu et autres

As a mechanosensitive channel, PIEZO1 translates mechanical stretching of cardiomyocytes into Ca 2+ signaling, underpinning the Frank-Starling law. This mechanism contributes to compensatory responses in heart failure. However, the relationship between PIEZO1 mutations and the development of cardiomyopathy remains unclear. Acute heart …

cn, th (code pays fourni par la source)

Abstract 4368865: Ly6C-Targeted LNP Delivery of CAR-ABCA1 mRNA Reprograms Macrophages for Enhanced Efferocytosis and Cholesterol Efflux in Atherosclerosis

Weiyan Li, Xueyi Weng, Juying Qian

Introduction: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid accumulation and defective clearance of apoptotic cells in plaques. Traditional LDL-C-lowering therapies such as statins show limited efficacy, as they fail to correct underlying metabolic imbalances. These imbalances cause anti-inflammatory macrophages …

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The association between angiographically derived radial wall strain and the risk of in-stent restenosis

Fang Zhang, Wei Gao, Jinying Zhou, Jingpu Wang et autres

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A novel angiographic index for predicting the efficacy of drug-coated balloons in small vessels

Ke Xu, Xi Fu, Wentao Yang, Yizhe Wu et autres

BACKGROUND: The drug delivery eï¬ciency of drug-coated balloons (DCBs) in de novo coronary artery disease is correlated with atherosclerotic plaque characteristics. It remains to be elucidated whether plaque composition and vulnerability can affect the efficacy of DCBs. AIMS: This study aimed to …

cn (code pays fourni par la source)