Christopher E. Ramsden

Ser423-phosphorylated MECP2 (MECP2-pS423) accumulates in human brain, cerebrospinal fluid and serum in sporadic Alzheimer’s disease

Qing-Rong Liu, Min Zhu, Kevin Perez, Qin Yao et autres

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Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals

Chee W. Chia, Eric Y. Tang, Roy G. Cutler, Susan S. You et autres

Under controlled environment of the clamps in healthy, non-obese men, cannabinoid receptor agonist enhanced whereas cannabinoid receptor 1 antagonist diminished insulin sensitivity in a dose-dependent manner. During the clamps, elevated plasma insulin levels had a suppressive effect on circulating non-esterified fatty acids …

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Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data

Jinyoung Park, K. Faurot, Zachary O. Kadro, Christopher E. Ramsden et autres

Background/Objectives: Increasing evidence supports the hypothesis that dietary intervention can improve pain among individuals with headaches, including migraine, a highly prevalent condition that can be disabling. Non-pharmacologic treatments for migraine are particularly attractive. In this secondary analysis of 182 participants enrolled in …

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Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data

J.Y. Park, Zachary O. Kadro, Gilson Honvoh, Anthony F. Domenichiello et autres

Background/Objectives: Increasing evidence supports the hypothesis that dietary intervention can improve pain among individuals with headaches, including migraine, a highly prevalent condition that can be disabling. Non-pharmacologic treatments for migraine are particularly attractive. In this secondary analysis of 182 participants enrolled in …

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Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues

Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak‐Hong, Katherine Ness Shipley et autres

Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega-3 and reducing omega-6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these …

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Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry

Jonghyun Bae, Zhaoyuan Gong, Caio Henrique Mazucanti, Murat Bilgel et autres

Abstract Background The Locus Coeruleus (LC) is a critical brain region affected by neurodegenerative diseases and aging. Despite its importance, in-vivo investigations of age-related LC degeneration and association with cognitive decline have been limited. Method We employed magnetic resonance relaxometry, namely the …

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A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial

Daisy Zamora, Kimbra Kenney, Mark S. Horowitz, Wesley R. Cole et autres

Targeted manipulation of dietary omega-3 and omega-6 fatty acids has previously been shown to decrease nontraumatic headaches in controlled trials. This study assessed the effects of a diet high in omega-3 fatty acids and low in omega-6 linoleic acid (H3L6 diet) on …

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Publisher Correction: Senolytic effects of a modified Gingerenone A

Ruin Moaddel, Chad Sanehira, Gregory S. Keyes, Chang‐Yi Cui et autres

In this article the author name ‘Ahmadkhania’ was incorrectly written and should have been ‘Ahmadkhaniha’. The original article has been corrected.

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Evidence for ApoE receptor 2-Disabled homolog-1 pathway disruption in the amygdala in sporadic Alzheimer’s disease

Christopher E. Ramsden, Mark S. Horowitz, Daisy Zamora, Thomas G. Beach et autres

INTRODUCTION: The ApoE receptor 2-Disabled homolog-1 (ApoER2-Dab1) pathway suppresses Tau phosphorylation as part of a multi-arm pathway that regulates cytoskeletal and synaptic integrity. We previously showed that multiple ApoER2-Dab1 pathway components accumulate in regions affected in early Alzheimer's disease (AD). Since the …

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Senolytic effects of a modified Gingerenone A

Ruin Moaddel, Chad Sanehira, Gregory S. Keyes, Chang‐Yi Cui et autres

Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very few senotherapeutic (senolytics …

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HYPOTHESIS: Lipid-protecting disulfide bridges are the missing molecular link between ApoE4 and sporadic Alzheimer's disease in humans

Christopher E. Ramsden, Roy G. Cutler, Xiufeng Li, Gregory S. Keyes

As the principal lipid transporter in the human brain, apolipoprotein E (ApoE) is tasked with transport and protection of highly vulnerable lipids that are required to support and remodel neuronal membranes, in a process that is dependent on ApoE receptors. APOE allele …

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Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light

Matthew R. Sapio, Diana King, Dragan Maric, Shilpan Shah et autres

Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of novel multiplex methods in human studies. In particular, lipofuscin (LF) is an interfering pigment in multiplex fluorescence assays. Lipofuscin (LF) is …

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