Matthew R. Sapio

Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia

Basak Donertas-Ayaz, Niall P Murphy, Airam Nicole Vivanco-Estela, Matthew R. Sapio et autres

Hypertension has been associated with altered nociceptive thresholds in humans and animal models, but the relationship between blood pressure (BP) and pain sensitivity remains inconsistent. Here, we investigated trigeminal nociception in male spontaneously hypertensive rats (SHRs) compared with normotensive Wistar-Kyoto (WKY) rats …

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Molecular Anatomy of GLP‐1 Signaling in the Human Nodose Ganglion

Matthew R. Sapio, Andrew J. Mannes

In this issue of The Journal of Comparative Neurology, Merchant et al. (2026) present comparative data defining glucagon-like peptide 1 receptor (GLP1R) expression in the mouse and human nodose ganglion, illuminating the molecular anatomy of the peripheral sensory targets of GLP-1 agonists.

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Proof-of-Concept Evaluation of the Oral Application of Resiniferatoxin for Pain Control in Feline Chronic Gingivostomatitis, a Translational Model of Human Oral Mucositis

Samay Shah, Matthew R. Sapio, Snigdha Chigurupati, Alvaro Cisternas et autres

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Targeting GPR183 to reduce peripheral sensitization: evidence from rodent and human tissue analyses

Kyle Oberkrom, Kathryn Braden, Evelyn Li, Samay Shah et autres

Abstract Peripheral sensitization is a key process in the development of painful inflammatory conditions, driven in part by immune-cell mediator release following tissue injury. The G protein–coupled receptor, GPR183, predominantly expressed on immune cells, regulates their migration, positioning, and mediator production. Yet …

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Longitudinal human transcriptomic and spatial gene profiling at the incisional edge during long surgical procedures

Matthew R. Sapio, Evelyn Li, Anthony F. Domenichiello, Taichi Goto et autres

Post-surgical pain remains a widespread problem reducing quality of life. The present study investigates the initial molecular changes underlying nociceptive sensitization through longitudinal, temporal sampling at the surgical wound edge. Using RNA-Seq and multiplex fluorescence in situ hybridization, we examined the most …

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Peppers and poppies: a perspective on nociceptors and pain control

Ellen S. Staedtler, Matthew R. Sapio, Andrew J. Mannes, Michael J. Iadarola

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Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues

Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak‐Hong, Katherine Shipley et autres

Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega-3 and reducing omega-6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these …

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RNA Extraction From Human Tissue Specimens for RNA-Seq v1

Matthew R. Sapio, Michael Dunkelberg, Mark Weiss, Geoffroy Laumet et autres

This protocol is optimized for extraction of RNA from a variety of human tissues, and is based on previous experience summarized in the referenced publications from the Department of Perioperative Medicine at the NIH Clinical Center. These procedures will result in high-quality …

Intraarticular resiniferatoxin, a potent TRPV1 agonist, for treatment of osteoarthritic pain

Michael J. Iadarola, Matthew R. Sapio, Alexis Nahama, Andrew J. Mannes

Clinical investigations of resiniferatoxin (RTX) analgesia are currently ongoing for several human pain indications. RTX is an agonist of the TRPV1 receptor cation ion channel which is activated by capsaicin, heat, and inflammatory conditions. RTX injection at peripheral sites of pain generation …

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Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models

A.K. Singh, Matteo Bernabucci, Nolan M. Dvorak, Zahra Haghighijoo et autres

Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirectionally modulates nociception, and that the FGF13/Nav1.7 ratio is upregulated in type 2 diabetic neuropathy …

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Treatment of Intractable Cancer Pain with Resiniferatoxin — An Interim Study

Andrew J. Mannes, John D. Heiss, Ann Berger, Christine Alewine et autres

BACKGROUND: A substantial number of patients with advanced cancer suffer from refractory pain despite comprehensive medical management. In this article, we evaluate a nonopioid analgesic, resiniferatoxin (RTX), a potent agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which selectively …

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Proof of Concept Study to Determine the Effectiveness and Safety of Oral Topical Application of Resiniferatoxin for the Control of Pain Associated with Feline Chronic Gingivostomatitis (FCGS)

Snigdha Chigurupati, Matthew R. Sapio, Alexis Namaha, Alvaro F. Cisternas et autres

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