Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data
Rattachement africain : us, Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: Increasing evidence supports the hypothesis that dietary intervention can improve pain among individuals with headaches, including migraine, a highly prevalent condition that can be disabling. Non-pharmacologic treatments for migraine are particularly attractive. In this secondary analysis of 182 participants enrolled in a randomized controlled trial of a dietary intervention designed to increase omega-3 (n-3) compared with a control diet, we examined the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both thought to decrease inflammatory processes. Methods: Path models with two time points (baseline and 16 weeks after randomization), were used to test the relationships between exposures of n-3 blood levels and self-reported dietary intake on outcomes of pain interference using the PROMIS pain interference scale and the Headache Impact Test (HIT-6). Model building was based on our published conceptual model. Results: Good fit was demonstrated for both models (EPA model: CFI = 0.984, RMSEA = 0.039, and SRMR = 0.045; DHA model: CFI = 0.981, RMSEA = 0.040, and SRMR = 0.040). Both EPA and DHA in the blood at 16 weeks were associated with lower levels of pain interference, but the effect for EPA was stronger (B = −0.56, p < 0.001 for EPA, and B = −0.43, p = 0.057 for DHA). Conclusions: Our findings are consistent with an indirect pathway linking diet to pain interference through blood levels of EPA and DHA in migraine.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data
- Date Crossref
- 19/12/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Duke University Department of Psychology and Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa Cape Town, Afrique du Sud (code pays fourni par la source)Organisation à but non lucratif
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Oakland University Department of Family Medicine and Community Health pays non établi dans la noticeUniversité ou école supérieure
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University of Washington Medical Center pays non établi dans la noticeÉtablissement de santé
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Fred Hutch Cancer Center pays non établi dans la noticeOrganisation à but non lucratif
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Beaumont Hospital pays non établi dans la noticeÉtablissement de santé
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Knoxville College pays non établi dans la noticeUniversité ou école supérieure
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University of Tennessee at Knoxville pays non établi dans la noticeUniversité ou école supérieure
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National Institute on Aging Lipid Peroxidation Unit pays non établi dans la noticeStructure de recherche
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University of North Carolina at Chapel Hill Department of Physical Medicine and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
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Cancer Prevention Program pays non établi dans la noticeInstitution
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University of Washington School of Medicine Department of Medical Oncology pays non établi dans la noticeUniversité ou école supérieure
Department of Psychology and Neuroscience — Duke University, Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (Cape Town, Afrique du Sud) et Department of Family Medicine and Community Health — Oakland University, avec 9 autres affiliations. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.