Anthony F. Domenichiello

A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial

Carol Moore, Duncan A. Sylvestre, Cora Davis, Jacques P. Arrieux et autres

Targeted manipulation of dietary omega-3 and omega-6 fatty acids has previously been shown to decrease nontraumatic headaches in controlled trials. This study assessed the effects of a diet high in omega-3 fatty acids and low in omega-6 linoleic acid (H3L6 diet) on …

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Longitudinal human transcriptomic and spatial gene profiling at the incisional edge during long surgical procedures

Matthew R. Sapio, Evelyn Li, Anthony F. Domenichiello, Taichi Goto et autres

Post-surgical pain remains a widespread problem reducing quality of life. The present study investigates the initial molecular changes underlying nociceptive sensitization through longitudinal, temporal sampling at the surgical wound edge. Using RNA-Seq and multiplex fluorescence in situ hybridization, we examined the most …

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Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data

J.Y. Park, Zachary O. Kadro, Gilson Honvoh, Anthony F. Domenichiello et autres

Background/Objectives: Increasing evidence supports the hypothesis that dietary intervention can improve pain among individuals with headaches, including migraine, a highly prevalent condition that can be disabling. Non-pharmacologic treatments for migraine are particularly attractive. In this secondary analysis of 182 participants enrolled in …

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A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial

Daisy Zamora, Kimbra Kenney, Mark S. Horowitz, Wesley R. Cole et autres

Targeted manipulation of dietary omega-3 and omega-6 fatty acids has previously been shown to decrease nontraumatic headaches in controlled trials. This study assessed the effects of a diet high in omega-3 fatty acids and low in omega-6 linoleic acid (H3L6 diet) on …

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Challenges, Lessons Learned, and Recommendations from an International Delphi to Develop Overarching Core Outcome Sets for Acute, Acute to Chronic, Recurrent/Episodic, and Chronic Pain

Giulia Bova, Janelle E. Letzen, Adam Anicich, Judy V. Birch et autres

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Lessons learned from the INTEGRATE-Pain Delphi process to develop core outcome sets (COS) across the pain continuum

Giulia Bova, Janelle E. Letzen, Adam Anicich, Judy V. Birch et autres

Dear Editor, The ability to compare results across studies is essential to ensuring that findings can be translated into improved treatments. To improve data comparison, core outcome sets (COS)—the minimum sets of outcomes to be measured—are increasingly being developed for health areas.6 …

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Tissue processing and RNA extraction for multi-omic molecular analyses of human surgical samples v1

Matthew R. Sapio, Evelyn Li, Anthony F. Domenichiello, Taichi Goto et autres

This protocol outlines the tissue collection and RNA extraction procedures for human tissue RNA extraction developed by Sapio and colleagues at the Department of Perioperative Medicine, Clinical Center. These procedures aim to describe a reproducible, scalable processing pipeline for multi-omic human tissue …

Mapping The Nociceptive Secretome from Human Incisional Skin Samples Collected During Long Thoracic Surgery

Evelyn Li, Matthew R. Sapio, Anthony F. Domenichiello, Alison Manalo et autres

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Developing consensus on core outcome sets of domains for acute, the transition from acute to chronic, recurrent/episodic, and chronic pain: results of the INTEGRATE-pain Delphi process

Giulia Bova, Anthony F. Domenichiello, Janelle E. Letzen, Daniela Constanze Rosenberger et autres

Background: Pain is the leading cause of disability worldwide among adults and effective treatment options remain elusive. Data harmonization efforts, such as through core outcome sets (COS), could improve care by highlighting cross-cutting pain mechanisms and treatments. Existing pain-related COS often focus …

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Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial

Amber B. Courville, Sharon F. Majchrzak‐Hong, Shanna B. Yang, Sara Turner et autres

Abstract The linoleic acid (LA)‐arachidonic acid (ARA)‐inflammatory axis suggests dietary LA lowering benefits health because it lowers ARA and ARA‐derived endocannabinoids (ECB). Dietary LA reduction increases concentrations of omega‐3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DHA derived ECB. The aim …

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INTEGRATE-Pain: a transatlantic consortium to advance development of effective pain management

Laura Dover Wandner, Petra Bloms‐Funke, Giulia Bova, Anthony F. Domenichiello et autres

Laura D Wandner, PhD, Petra Bloms-Funke, PhD, Giulia Bova, MA, Anthony Domenichiello, PhD, Anja Hoffmann, MD, Smriti Iyengar, PhD, Barbara I Karp, MD, Janelle L

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Endogenous Derivatives of Linoleic Acid and their Stable Analogs Are Potential Pain Mediators

Joshua J. Wheeler, Anthony F. Domenichiello, Jennifer Jensen, Gregory S. Keyes et autres

Psoriasis is characterized by intense pruritus, with a subset of individuals with psoriasis experiencing thermal hypersensitivity. However, the pathophysiology of thermal hypersensitivity in psoriasis and other skin conditions remains enigmatic. Linoleic acid is an omega-6 fatty acid that is concentrated in the …

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